Coeliac disease profile-2 Comprehensive

Celiac disease, also known as gluten-sensitive enteropathy, is an autoimmune reaction to eating gluten, a protein found in wheat, barley and rye.
Eating gluten triggers an immune response in small intestine which may damage your small intestine's lining and prevents it from absorbing some nutrients (malabsorption). This can lead to diarrhea, fatigue, weight loss, bloating and anemia. 
It can also lead to dermatitis
Disease is incurable but following a strict gluten-free diet can help patients to live a symptom free life. Various laboratory celiac disease tests are available to diagnose this condition namely antibodies against tTG, endomysium & gliadin. Presence of HLA DQ 2 & 8 is associated with this disease

Overview

Gluten, a protein present in wheat, barley, and rye, causes coeliac disease, sometimes referred to as gluten-sensitive enteropathy. When you consume gluten, your small intestine has an immunological reaction that may cause lining damage and impair your ability to absorb some nutrients. Coeliac disease can affect both adults and kids. It is a rare genetic disease that is linked to the presence of HLA DQ2 and DQ8 genes, and the illness is likely underdiagnosed. The syndrome is characterized by a hypersensitivity to gluten resulting in malabsorption, small intestine villi swelling and atrophy, and other symptoms, such as diarrhoea, exhaustion, weight loss, bloating, anaemia and dermatitis. A Coeliac Disease Profile 2 test is done to evaluate gluten intolerance. Here is all you need to know about the test.

The Coeliac Disease Profile 2 test is a comprehensive profiling test that tests for several parameters, including those for antibodies to tTG, endomysium, and gliadin. This test helps to diagnose coeliac disease based on the evaluation of the abovementioned parameters. Although the condition is incurable, adhering to a rigorous gluten-free diet can enable individuals to live symptom-free lives.

Depending upon your condition and symptoms, your doctor may also test for the following along with the Coeliac Disease Profile 2 Test:

• Type 1 diabetes autoimmune hepatitis
• Primary sclerosing cholangitis
• Primary biliary cholangitis
• Liver diseases like autoimmune hepatitis
• Thyroid diseases like Hashimoto's disease, Graves' disease, and Addison's disease

Written by: Dr Vishal Wadhwa M.D, D.N.B Microbiology, Medical Affairs