back-arrow-image Search Health Packages, Tests & More

Coeliac disease profile-2 Comprehensive

50+ booked in last 3 days

Celiac Disease Test Overview

Celiac disease, also known as gluten-sensitive enteropathy, is an autoimmune reaction to eating gluten, a protein found in wheat, barley and rye.
Eating gluten triggers an immune response in small intestine which may damage your small intestine's lining and prevents it from absorbing some nutrients (malabsorption). This can lead to diarrhea, fatigue, weight loss, bloating and anemia. 
It can also lead to dermatitis
Disease is incurable but following a strict gluten-free diet can help patients to live a symptom free life. Various laboratory celiac disease tests are available to diagnose this condition namely antibodies against tTG, endomysium & gliadin. Presence of HLA DQ 2 & 8 is associated with this disease


Gluten, a protein present in wheat, barley, and rye, causes coeliac disease, sometimes referred to as gluten-sensitive enteropathy. When you consume gluten, your small intestine has an immunological reaction that may cause lining damage and impair your ability to absorb some nutrients. Coeliac disease can affect both adults and kids. It is a rare genetic disease that is linked to the presence of HLA DQ2 and DQ8 genes, and the illness is likely underdiagnosed. The syndrome is characterized by a hypersensitivity to gluten resulting in malabsorption, small intestine villi swelling and atrophy, and other symptoms, such as diarrhoea, exhaustion, weight loss, bloating, anaemia and dermatitis. A Coeliac Disease Profile 2 test is done to evaluate gluten intolerance. Here is all you need to know about the test.

The Coeliac Disease Profile 2 test is a comprehensive profiling test that tests for several parameters, including those for antibodies to tTG, endomysium, and gliadin. This test helps to diagnose coeliac disease based on the evaluation of the abovementioned parameters. Although the condition is incurable, adhering to a rigorous gluten-free diet can enable individuals to live symptom-free lives.

Depending upon your condition and symptoms, your doctor may also test for the following along with the Coeliac Disease Profile 2 Test:

  • Type 1 diabetes autoimmune hepatitis
  • Primary sclerosing cholangitis
  • Primary biliary cholangitis
  • Liver diseases like autoimmune hepatitis
  • Thyroid diseases like Hashimoto's disease, Graves' disease, and Addison's disease

Written by: Dr Vishal Wadhwa M.D, D.N.B Microbiology, Medical Affairs

Read More

Coeliac disease profile-2 Comprehensive Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Coeliac disease profile-2 Comprehensive with a clear pricing structure.

The Coeliac disease profile-2 Comprehensive Price in Mumbai is ₹ 10,495 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

This profile contains all the tests required for diagnosis of Coeliac disease. Definitive diagnosis is achieved through jejunal biopsy demonstrating villous atrophy. To avoid unnecessary biopsy a battery of the tests can be judiciously interpreted

All of the tests necessary for the diagnosis of coeliac disease are included in this profile. This battery of tests can be wisely interpreted to prevent needless biopsies. By establishing villous atrophy during the jejunal biopsy, a definitive diagnosis is made when necessary.

Individual tests in this profile are available to measure tTG IgA, Endomysial antibody IgA, Gliadin IgA/G and presence of HLA DQ2 & HLA DQ8 type

Celiac disease test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer. Sample may be collected in serum and ACD tube

To test for antibodies like anti-tTG, quantitative immunoglobulin A (IgA), and deamidated gliadin peptide (DGP) antibodies, a sample of your blood is obtained. The site of injection will be cleaned with alcohol before obtaining the sample. An elastic band will be tightly fastened across your upper arm and you will be asked to make a fist. This will stop the blood flow and fill the vein from where blood will be collected. A needle will be inserted and blood collected in a vacutainer. This might feel like a prick and tenderness in the area, if any, will resolve in some time.

tTG IgA is the best test to start with unless patient is less than 2 years or IgA deficient, in such a case Gliadin IgG is preferred. For IgA deficient patients tTG IgG may be used.
If tTG IgA results are positive one may proceed for confirmatory test (biopsy). If results are equivocal then test for gliadin and endomysial antibody, which if found positive then proceed for confirmatory test. If gliadin & endomysial antibody are negative then test for presence of HLA DQ 2 and HLA DQ 8. Absence of these two HLA indicates patient is not having coeliac disease (this test if positive is not conclusive)

Individuals suffering from symptoms, such as diarrhoea, bloating, weight loss, anaemia, dermatitis, and exhaustion, and having a family history of coeliac disease should get themselves tested.

To avoid pointless testing, genetic testing is advised for celiac disease in relatives, especially youngsters. Every three to five years, screening first-degree relatives who are gene positive is recommended.

Only those with specific genes are susceptible to developing coeliac disease. If a member of your family has coeliac disease, you are much more likely to get it yourself. All across the world, celiac disease affects both children and adults. Females are diagnosed with celiac disease more frequently than males are. Those suffering from the symptoms of coeliac disease mentioned above should go for the test.

Your family's medical history, the foods you have been eating, and your medical history should all be disclosed to the doctor. The doctor will provide certain instructions which should be observed for a precise outcome based on the data given. As it is a blood test, it is best to dress comfortably so the doctor may easily draw a blood sample.

  1. Celiac sprue
  2. Nontropical sprue
  3. Gluten-sensitive enteropathy
  4. Gliadin Antibody IgG
  5. Gliadin Antibody IgA
  6. Tissue transglutaminase IgA (tTg IgA)
  7. Endomysial IgA
  8. Human Leukocyte Antigens
  9. HLA DQ2
  10. HLA DQ8
full medical check up

Ratings & Reviews (0)

No reviews available

Why Metropolis?

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.

lab image
170+ Advanced Labs
lab image
Trusted by Leading Doctors & Hospitals
lab images
Over 2000+ Scientific Officers
reports image
Proficiency Testing for Accurate Reports

Latest Blogs & News

View More
View all