Amphiphysin Antibody Neuronal Ag in Paraneoplastic Syndrome Serum

Anti-Amphiphysin Antibody Test Overview

The anti-amphiphysin antibody test is a specialised diagnostic tool used to detect the presence of autoantibodies directed against the amphiphysin protein in the blood. These antibodies are associated with various paraneoplastic neurological syndromes (PNS) and certain types of cancers, particularly small-cell lung cancer and breast cancer. The amphiphysin protein is found in synaptic vesicles and plays a crucial role in neurotransmitter release.

The anti-amphiphysin antibody test is an important tool for identifying individuals who may be experiencing neurological symptoms due to an underlying tumour or autoimmune condition. It helps healthcare providers diagnose and manage paraneoplastic neurological syndromes, monitor tumour recurrence, and guide appropriate treatment strategies. By detecting the presence of anti-amphiphysin antibodies, this test contributes to the early identification and management of potentially serious conditions.

Amphiphysin is a protein found in nerve cells, and these antibodies are produced when your immune system mistakenly attacks the nerve cells in your body. Amphiphysin plays a crucial role in cellular processes and is also associated with certain neurological disorders.