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G6pd Test Overview
Glucose -6-Phosphate dehydrogenase (G-6-PD) is a protein that prevents the destruction of the cells by free radicals building up in the body. Abnormality of the enzyme causes RBC's to break down prematurely. G6PD deficiency is one of the most common enzyme deficiency worldwide causing a spectrum of diseases including neonatal hyperbilirubinemia, acute hemolysis, and chronic hemolysis. This is a X-linked inherited disorder and more than 300 different types of G-6-PD variants have been described.
What is glucose-6-phosphate dehydrogenase (G6PD)?
G6PD is a common enzyme found in red blood cells. It helps convert glucose into energy and prevents oxidative damage to red blood cells. When enzymes convert oxygen molecules into free radicals, which can damage cells, oxidative damage occurs.
Free radicals are unstable molecules that can cause oxidative stress, which can lead to serious diseases such as cancer and cardiovascular disease. G6PD protects cells from these potentially dangerous molecules. Without sufficient amounts of the G6PD, red blood cells become fragile and more susceptible to destruction, resulting in hemolytic anaemia.
A G6PD test can assist healthcare providers in determining a patient's risk of G6PD deficiency and ensuring they receive the necessary treatment to prevent complications.
Written by: Dr.Shibani R, Medical Writer, Medical Affairs
G6PD Qualitative Blood Test Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the G6PD Qualitative Blood Test with a clear pricing structure.
The G6PD Qualitative Blood Test Price in Mumbai is ₹ 850 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
G6pd test is done in patients suspected to be G6PD deficient. Patients include cases of neonatal hyperbilirubinemia, acute hemolysis, and chronic hemolysis. The usual triggers for hemolysis include :
- Bacterial infections
- Certain medications like antibiotics and NSAIDs.
- In babies with unresolving jaundice.
The glucose-6-phosphate dehydrogenase (G6PD) test is done for the following reasons:
- It helps to find out if you have G6PD deficiency and treat it before it gets worse.
- For finding the underlying cause of persistent jaundice in infants or babies suffering from it for more than two weeks without any obvious cause.
- To confirm the presence of haemolytic anaemia in adults experiencing symptoms like
- Increased spleen size.
- Light skin.
- Higher heart rate.
- Dark-coloured urine.
Typically, the G6PD qualitative blood test is recommended for anyone with a family history of G6PD deficiency. However, it is also recommended for:
- Patients who are thought to be G6PD deficient.
- Patients with chronic haemolysis, acute haemolysis, and neonatal hyperbilirubinemia.
- People experiencing the following symptoms of haemolysis:
- Bacterial infections.
- Reactions to medications such as NSAIDs and antibiotics.
- Persistent jaundice, in infants.
The test is also suggested for people who show signs of haemolytic anaemia after being exposed to certain drugs, conditions, or foods, such as:
- Certain Antibiotics.
- Anti-Malarial Drugs.
- Bacterial Infections.
- Viral Infections.
- Fava Beans/Broad Beans (Favism).
- Nonsteroidal Anti-Inflammatory Drugs (Aspirin and Ibuprofen).
G6pd test detects presence G6PD enzyme as deficient or not deficient
The glucose-6-phosphate dehydrogenase qualitative test measures the amount of G6PD in the blood.
During G6pd test blood sample is taken from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
G6PD deficient patients may suffer from hemolytic episodes and jaundice when exposed to a trigger; in absence of a trigger they are usually asymptomatic. G6PD not deficient results are considered normal. Result may come false not deficient in case a G6PD deficient person is tested during hemolytic episode.
Inquire with your medical professional if the test requires any particular preparation. Certain meals and medications may affect the outcomes of your tests.
Anaemia is a condition when the body doesn't produce enough healthy red blood cells to deliver oxygen to the tissues. Fatigue, pale skin, dizziness and shortness of breath, are some anaemia symptoms.
When RBCs get too old, a normal biological process called haemolysis takes place. RBCs start to lose specific characteristics and function less effectively as they get older. For instance, they might lose the ability to deform, which enables them to alter shape to flow through blood vessels.
A healthcare provider may suggest the following tests along with the G6PD qualitative test:
Complete Blood Count (CBC):
The complete blood count (CBC) is a panel of tests used to measure the different components of the blood, including red blood cells, white blood cells, platelets, haemoglobin, and hematocrit.
Serum Haemoglobin Test:
The serum haemoglobin test measures the concentration of haemoglobin in the blood. This test is useful for diagnosing anaemia because it can determine whether the condition is due to a decrease in red blood cells or haemoglobin.
The reticulocyte count is a blood test that measures the quantity of immature red blood cells. It is used to aid in the diagnosis, monitoring, and evaluation of the efficacy of anaemia treatments.
- Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Test.
- Glucose-6-Phosphate Dehydrogenase Test.
- G6PD Deficiency Test.
- G6PD Test.
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