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EGFR Mutation Detection Test (EXONS 18, 19, 20, 21)

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EGFR Mutation Test Overview

EFGR mutations are most commonly seen in Non-Small Cell Lung Cancer (NSCLC) adenocarcinomas. EFGR mutations tend to occur in women with little or no smoking history. The doctor may recommend testing if they suspect one has lung cancer. A biopsy is recommended if a person is already diagnosed with lung cancer, or if there is a recurrence of tumours in the patient.
Up to 20% of NSCLC tumors harbour the EGFR mutation in Exons 18-21, and that ~85% of patients with these patients respond to TKI treatment.

It’s pertinent that anyone with a diagnosis of lung cancer or those who are suspected of the disease should ask their doctor whether to get tested for EFGR. The doctor can use the same biopsy tissue used to diagnose lung cancer for testing for mutations.

Exons and introns are nucleic acid sequences made up of the polynucleotide chain. However, the structure of introns is more complex with high GC-rich regions and repetitive sequences. Both the exons and introns take part in protein formation and follow the DNA packaging mechanism to fit inside a cell.

Written by: Dr Vishal Wadhwa, M.D, D.N.B Microbiology, Medical Affairs

 

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EGFR Mutation Detection Test (EXONS 18, 19, 20, 21) Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the EGFR Mutation Detection Test (EXONS 18, 19, 20, 21) with a clear pricing structure.

The EGFR Mutation Detection Test (EXONS 18, 19, 20, 21) Price in Mumbai is ₹ 8,480 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

EGFR Mutation test is done to detect mutations in EGFR gene in exons 18 to 21. Patients with mutations respond well to TKI treatment

  • To detect mutations in the EGFR gene in exons 18 to 21
  • Patients with mutations respond well to TKI treatment
  • Helps in formulating the proper treatment plan
  • The test is done during or after the diagnosis of NSCLC to find out
    1. Whether you have a disease or condition
    2. How aggressive is your disease or condition is
    3. How well you’ll respond to specific treatments

EGFR Mutation test detects mutations in EGFR gene with real time PCR

Sample is provided by the recommending doctor. Tumor containing FFPE block (>10% of tumor). Tumor containing tissue fixed in 10% neutral buffered formalin with duration of 6 to 72 hours

The sample for testing is provided by the doctor. The samples may consist of:

  • Tumour containing > 10% of FFPE block.

Tumours containing the tissue fixed with 10% neutral buffered formalin within a duration of about 6 to 72 hours

Patients with EGFR mutation respond well to TKI treatment. KRAS mutations are associated with intrinsic
Tyrosine Kinase (TKI) resistance. Hence, KRAS codon 12/13 mutation testing would be useful for selection of the patients for TKI therapy.
Patients who are negative for EGFR mutations can additionally be tested for ALK rearrangement and the ALK positive NSCLC cases are likely to benefit from FDA approved crizotinib (XALKORI) therapy
Patients with PD-L1 expression predicts potential response to immunotherapy such as nivolumab and pembrolizumab

Those diagnosed with NSCLC are recommended to get the EGFR Mutation Detection Test done to decide on the type of treatment to be pursued.
 

The EGFR Mutation Detection Test can be done when NSCLC is detected in the lungs of the patient. It can be used to determine the mode of treatment depending on the types of gene mutations.
 

No particular preparation is required for the EGFR mutation detection test. The doctor must be informed of any underlying medical conditions, medicines taken and any allergies one may be having.
 

It is suggested to get this test done if the following symptoms of NSCLC are present in a person:

  • Frequent cough
  • Shortness of breath
  • Blood in cough
  • Pain in the back
  • Pain in the shoulders
  • Chest pain
  • Repeated respiratory infections
  • Fatigue
  • Depression
  • Blood clots
  • Sudden weight loss
  • Face and neck swelling
  • Swollen lymph nodes in the neck and upper chest
  • Clubbing
  • Reduced energy
  • Jaundice
  • Change in balance or strength
     

Most of those afflicted with NSCLC get diagnosed at a very late stage of cancer. It is because many of the symptoms of NSCLC are mistaken for the effects of those who smoke in the long term. Owing to this, 80% of those who have NSCLC have already progressed to the later stages making it much more difficult to treat. When present in the lungs, it can cause many complications such as shortness of breath, and a bluish tint to the skin and lips known as cyanosis. NSCLC is the most common type of lung cancer. Like most cancers, it is caused by genetic mutations that cause the cells in the lung to multiply rapidly leading to the development of tumours in the lungs.

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We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.

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