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BOH Profile Test - BOH (Bad Obstetric History) Profile-Maxi Karyotyping couple
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Blood
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Male, Female
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Overview
The BOH (Bad Obstetric History) Profile Test is a comprehensive diagnostic tool designed to identify the underlying causes of unfavourable pregnancy outcomes, such as recurrent pregnancy losses, spontaneous abortions, stillbirths, early neonatal deaths, intrauterine growth retardation, and congenital anomalies. A BOH profile test is particularly recommended for women who have experienced multiple failed pregnancies to help determine the root cause and guide appropriate treatment.
Bad Obstetric History (BOH) refers to unfavourable pregnancy or foetal outcomes which includes failed pregnancies, two or more spontaneous abortions, early neonatal deaths, stillbirths, intrauterine growth retardation and congenital anomalies. Women with multiple failed pregnancies can undergo BOH test. The reasons for pregnancy loss may include maternal infections, blood coagulation factors, presence of autoantibodies, hormonal and genetic factors. The profile test helps to detect and underlying cause and the subsequent treatment.
Written by - Dr. Shibani R, Medical Writer, Medical Affairs
Reasons for Undergoing the BOH Profile Test
The BOH panel test helps diagnose and identify potential causes of adverse pregnancy outcomes. It is recommended for individuals with:
- Recurrent Pregnancy Losses: Two or more spontaneous abortions, indicating possible genetic, hormonal, or immune issues.
- Stillbirths: Unexplained foetal death in utero, which may be linked to infections, chromosomal abnormalities, or maternal conditions.
- Early Neonatal Deaths: Infant death shortly after birth, often due to genetic disorders, infections, or placental insufficiency.
- Intrauterine Growth Retardation (IUGR): Poor fetal growth, potentially caused by placental dysfunction, infections, or maternal health conditions.
- Congenital Anomalies: Birth defects that may result from genetic mutations, infections, or environmental factors.
- Family History: A background of pregnancy complications, suggesting hereditary or immunological factors.
This test aids in early diagnosis, risk assessment, and management strategies to improve pregnancy outcomes.
What Causes Bad Obstetric History?
Bad Obstetric History (BOH) refers to multiple pregnancy complications that can lead to adverse outcomes, such as miscarriage, stillbirth, or neonatal death. Understanding what causes BOH can help you make informed decisions about your health. These causes can be complex, but knowing the possible factors can provide clarity.
Common causes of BOH include:
- Genetic abnormalities in either parent, which can lead to recurrent miscarriages or birth defects.
- Infections such as bacterial or viral infections (e.g., TORCH infections), which can harm the fetus.
- Hormonal imbalances, like thyroid issues, can prevent a pregnancy from progressing properly.
- Autoimmune disorders, such as antiphospholipid syndrome (APS), which can cause blood clots, leading to pregnancy loss.
- Placental issues, where the placenta doesn't work effectively to support the baby’s growth.
Identifying the underlying cause of your BOH is crucial, as it guides your healthcare provider in creating a treatment plan that may help improve pregnancy outcomes.
Why Is The BOH Panel Test Required?
If you have experienced multiple pregnancy losses, the BOH Profile Test can be a crucial step in understanding why this is happening. The test aims to identify specific factors contributing to pregnancy complications and helps guide the right treatment options for future pregnancies.
The BOH panel test is recommended for:
- Recurrent pregnancy losses: If you’ve experienced two or more consecutive miscarriages, the BOH panel can help identify underlying genetic, hormonal, or immunological factors.
- Stillbirths or early neonatal deaths: The test helps uncover possible causes like infections, chromosomal issues, or maternal health conditions.
- Intrauterine growth retardation (IUGR): It helps identify causes such as placental dysfunction or maternal health issues.
- Congenital anomalies: Birth defects can sometimes be linked to genetic abnormalities or infections.
By identifying the cause, the BOH Profile Test enables early intervention, increasing the chances of a healthier pregnancy in the future. It offers peace of mind and the clarity needed to proceed with appropriate treatment options.
What Are The Test Parameters In The BOH Panel Test?
The BOH Profile Test evaluates several crucial parameters that may be causing pregnancy complications. These tests help your healthcare provider understand what’s affecting your pregnancy outcomes. The BOH panel is a comprehensive screening that checks for genetic, infectious, immunological, and hormonal factors. It includes 21 parameters such as:
Genetic tests:
- Karyotyping by G-banding (husband & wife)
Infectious disease screening (TORCH panel):
- Toxoplasma IgG & IgM antibodies
- Rubella virus IgG & IgM antibodies
- Cytomegalovirus (CMV) IgG & IgM antibodies
- Herpes Simplex Virus type 1 (HSV-1) IgG & IgM antibodies
- Herpes Simplex Virus type 2 (HSV-2) IgG & IgM antibodies
Avidity testing:
- Toxoplasma avidity test
- Rubella virus avidity test
- CMV avidity test
Autoimmune antibody tests:
- Anti-Nuclear Antibody (ANA) screening
- Lupus anticoagulant profile (APTT, mixing studies, RVVT screen & confirmation)
- Antiphospholipid antibody panel (APA-IgG, APA-IgM)
- Cardiolipin antibodies (ACL-IgG, ACL-IgM)
Endocrine markers:
- Thyroid Stimulating Hormone (TSH, ultrasensitive)
- Prolactin
By examining these factors, the test provides insights into the causes of BOH and helps tailor treatment plans.
Procedure For The BOH Profile Test
The BOH Profile Test is relatively simple and straightforward.
Here is what you can expect during the process:
- Fasting: Fasting is generally not required for all BOH profile components, but your doctor may recommend it for certain hormonal or metabolic subtests. Follow the specific instructions provided with your booking.
- Sample collection: A healthcare professional will collect a blood sample, usually from your arm.
- Home collection: If you prefer, you can request home blood collection services for your convenience.
- Lab analysis: The sample is sent to an accredited lab for detailed analysis, which may take 1-2 days.
- Report: Report turnaround is typically up to 15 days, as genetic and specialised antibody tests require extended processing time..
Though the procedure might seem overwhelming, rest assured that the process is quick, easy, and helps provide valuable information for better managing your pregnancy journey.
How Do I Treat Or Manage BOH?
Managing Bad Obstetric History is not about one-size-fits-all solutions. Once the cause of your BOH is identified, treatment can be tailored to your specific situation. The goal is to improve your chances of a healthy pregnancy in the future.
Here are some ways to manage or treat BOH:
- Lifestyle changes: Maintaining a healthy weight, eating well, and managing stress can improve your overall health and pregnancy outcomes.
- Medication: Depending on the underlying cause, your healthcare provider may prescribe medications like anticoagulants, hormones, or antibiotics to address specific issues.
- Fertility treatments: In some cases, assisted reproductive technologies (ART) like IVF may be suggested, especially if genetic or chromosomal issues are involved.
- Monitoring: Regular check-ups and monitoring during pregnancy, including more frequent ultrasounds, can help catch potential complications early.
The management approach depends on the test results, but with the right treatment, many women with BOH can have successful pregnancies. Your healthcare provider will guide you through each step with compassion and support.
Conclusion
The BOH Profile Test is an essential tool for identifying underlying causes of pregnancy complications, such as recurrent miscarriages, stillbirths, and neonatal deaths. With its comprehensive testing, BOH Profile Test helps healthcare providers offer personalised solutions to improve pregnancy outcomes.
For reliable, accurate, and timely results, opt for Metropolis Healthcare. With over 40 years of expertise and NABL & CAP-accredited labs, they ensure that you receive the best diagnostic care in a seamless and accessible manner.
List of Parameters Considered During the BOH Profile Test
The BOH profile test evaluates pregnancy complications through:
- Karyotype Analysis: Detects chromosomal abnormalities like monosomy or trisomy
- Infection Screening: Identifies infections via TORCH tests
- Endocrine Monitoring: Assesses hormone levels (prolactin, TSH) affecting pregnancy
- Autoantibody Screening: Detects APLA for diagnosing antiphospholipid syndrome (APLS)
BOH Profile Test Preparation
Overnight fasting of 10-12 hours is usually recommended before the blood sample collection for a BOH panel test. If the patient is on heparin, it should be discontinued for at least one day, and oral anticoagulants should be stopped for 7 days before the test, but only after consulting the healthcare provider.
BOH Profile Test Results & Interpretation
The results of the BOH profile test can be either positive or negative for each parameter tested:
- Positive Results: Indicate the presence of specific issues such as chromosomal abnormalities, infections, hormonal imbalances, or autoantibodies, which can guide targeted treatments. For example, a positive result for antiphospholipid antibodies may indicate antiphospholipid syndrome, and appropriate medications can be prescribed to reduce the risk of blood clots.
- Negative Results: Suggest that the tested parameters are within normal ranges, which may help rule out certain causes of bad obstetric history.
The results should be interpreted by a healthcare provider who can correlate the findings with the patient's clinical history and other diagnostic tests to formulate a comprehensive treatment plan.
Home Collection for BOH Profile Test Near You
Home collection for the BOH profile test offers a convenient solution for individuals to get tested without visiting a clinic. With Metropolis Healthcare's lab services, a trained phlebotomist comes to your doorstep to collect blood samples. This service ensures comfort and safety while maintaining high standards of sample handling and testing accuracy. Patients can expect a seamless experience with timely and reliable results, empowering them to take proactive steps in managing their health.
Metropolis Healthcare's commitment to accessible healthcare underscores its dedication to providing quality diagnostic solutions conveniently at home.
BOH Profile Test Price In Different Cities
The BOH Profile test price can vary depending on your location. Below is an overview of the test price range in various cities across India:
|
City |
Approximate Cost (INR) |
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₹ 14000 to ₹ 16000 |
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₹ 14000 to ₹ 16000 |
|
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₹ 14000 to ₹ 16000 |
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₹ 14000 to ₹ 16000 |
These prices may slightly vary depending on the lab and any additional services such as home collection or specialised tests. However, most labs offer transparent pricing and ensure you get quality results.
If you are concerned about cost, know that Metropolis Healthcare is committed to providing affordable, accessible diagnostic services across India.
BOH Profile Test - BOH (Bad Obstetric History) Profile-Maxi Karyotyping couple Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the BOH Profile Test - BOH (Bad Obstetric History) Profile-Maxi Karyotyping couple with a clear pricing structure.
The BOH Profile Test - BOH (Bad Obstetric History) Profile-Maxi Karyotyping couple Price in Mumbai is ₹ 15,750 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
BOH (Bad Obstetric History) Profile-Maxi includes the ANA, APA-IgG / IgM, ACAIgG / IgM, LAC, TSH, TORCH-13 tests. Apart from this the Karyotyping of Couple is also done.
The test is done to diagnose and detect causes for failed pregnancies, spontaneous abortions, neonatal deaths, stillborn etc. These may include:
- Thyroid dysfunction
- Infections, especially TORCH
- Anatomical factors
- Thrombophilia
- Coagulation Disorders
- Autoimmune disorders.
- Genetic causes (diagnosed through Karyotyping, subsequent tests may be suggested if abnormality is detected)
- Couples experiencing consecutive spontaneous abortions.
- Couples having difficulty conceiving or experiencing multiple failed pregnancies.
- Women having difficulty in the current or previous pregnancy; like foetal growth retardation, early neonatal deaths, stillborn.
This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer. For couple karyotyping blood sample of both husband and wife is required.
No special precautions.
LAC test
Abnormal APTT levels and presence of Lupus anti-coagulant antibody may occur in cases of recurrent abortions. The results may be transient and persisting.
Cardiolipin AntibodyACL- IgG
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and are associated with thrombotic states and can cause recurrent abortions and infertility.
TORCH-13
Presence of antibodies against the infections under the TORCH complex may indicate maternal infections which increases the risk of transmission to foetus and may lead to foetal abnormalities and abortion.
- ANA Test
- APA test
- ACA test
- LAC test
- TSH
- TORCH-13 test
- Couple Karyotyping test
: Presence of Anti-nuclear antibodies are associated with autoimmune diseases which can cause infertility and pregnancy loss.
Anti-Cardiolipin Aantibodies (ACA) are autoimmune in nature and are associated with thrombotic states and can cause recurrent abortions.
Lupus anticoagulants are antibodies detected that are associated with a thrombotic tendency and clinical states such as recurrent abortions. Their presence may be persistent or transiting.
This includes tests to detect infections or antibodies under the TORCH complex i.e. Toxoplasmosis, Rubella infections, Herpes Simplex and Cytomegalo Virus (CMV) infections. These infectious agents can cause abortion but usually are not seen as a cause of recurrent pregnancy failure. Testing both IgG and IgM antibodies can help in timing of infection acquisition.
Couple karyotyping is done in couples experiencing recurrent pregnancy loss and abortions to detect any gross structural anomalies, microdeletions, microduplications, single gene disorders that may be contributing to pregnancy loss.
Tests for thyroid hormones help in detecting any hormonal causes for recurrent pregnancy loss.
The BOH profile test, also known as the BOH panel test, is a comprehensive diagnostic tool that helps identify the underlying causes of recurrent pregnancy losses, stillbirths, congenital anomalies, and other unfavourable pregnancy outcomes in women with a history of such issues.
Yes, some diagnostic laboratories like Metropolis Healthcare offer home sample collection services for the BOH profile test, ensuring convenience and comfort for patients.
The BOH profile test is used to diagnose and detect the underlying causes of adverse pregnancy outcomes, such as recurrent miscarriages, stillbirths, early neonatal deaths, intrauterine growth retardation, and congenital anomalies in women with a history of bad obstetric outcomes.
The normal range for a BOH profile test is not a single value but rather the absence of specific abnormalities in the parameters tested, such as normal karyotype analysis, absence of infections, normal hormone levels, and absence of autoantibodies.
Women who have experienced multiple adverse pregnancy outcomes, including recurrent pregnancy losses, stillbirths, early neonatal deaths, intrauterine growth retardation, or congenital anomalies, are eligible for the BOH profile test.
The BOH profile test offers several benefits, including identifying the underlying causes of bad obstetric history, guiding targeted treatments, and improving the chances of a successful pregnancy. By addressing specific issues like hormonal imbalances, infections, and genetic factors, the test helps reduce the risk of future pregnancy complications, providing valuable insights and peace of mind for women with a history of adverse pregnancy outcomes.
The frequency of testing for a BOH profile test depends on individual clinical needs and the recommendations of your healthcare provider.
The BOH profile test can be done at any time as recommended by your healthcare provider.
Yes, overnight fasting of 10-12 hours is usually recommended before the blood sample collection for the BOH profile test.
Yes, patients should discontinue any anticoagulant medications as advised by their healthcare provider before the BOH profile test.
The BOH profile test includes several parameters, such as karyotype analysis, infection screening (e.g., TORCH infection test), endocrine monitoring (e.g., prolactin, anti-thyroid antibodies, TSH), and autoantibody screening (e.g., antiphospholipid antibodies).
The BOH profile test involves collecting blood samples from the patient, which are then analysed in a laboratory for various parameters.
The BOH profile test should be done after a woman has experienced multiple adverse pregnancy outcomes, such as recurrent miscarriages, stillbirths, or congenital anomalies, and before attempting another pregnancy, as recommended by a healthcare provider.
The BOH profile test becomes positive when specific abnormalities are detected in the parameters tested, such as chromosomal abnormalities, the presence of infections, hormonal imbalances, or autoantibodies, indicating the underlying causes of bad obstetric history.
The sample collection for a BOH profile test usually takes only a few minutes, as it involves drawing blood from the patient's vein.
The turnaround time for BOH profile test reports may vary depending on the lab and the complexity of the tests performed, but typically, the results are available within 15 days based on the day/time when the sample was collected and processed.
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