BCR-ABL Breakpoint Analysis Qualitative By Real Time PCR - Blood

This test analyzes the breakpoints (major, minor, and micro translocations) of BCR-ABL fusion gene.

• To diagnose CML • To monitor the effectiveness of treatment for CML • To detect major, minor, and micro translocations of the BCR-ABL gene in other cases where it may be present

BCR-ABL Breakpoint Analysis may be recommended if you have • symptoms suggestive of Chronic Myeloid Leukemia (CML) such as unexplained weight loss, fatigue, or enlarged spleen, • abnormal blood cell counts or other hematological abnormalities, • aprevious diagnosis of CML to monitor treatment response and remission, or • a family history or genetic risk factors for CML.

Abnormal results may suggest the presence of CML or other conditions associated with BCR-ABL gene fusion.

A blood sample will be collected from your vein using a needle. The sample will be sent to the laboratory for analysis.

• No specific preparation is required for this test. • Inform your doctor about any relevant clinical history and medications you are taking. Also, tell them if you have any specific requirements.

• Complete Blood Count (CBC) • Bone Marrow Aspiration and Biopsy for further evaluation of haematological abnormalities • Other genetic tests to assess additional mutations or abnormalities associated with CML

BCR-ABL Fusion Gene Analysis or BCR-ABL Transcript Detection

Chronic Myeloid Leukaemia is a type of blood cancer that starts in the bone marrow. It is characterised by the presence of the BCR-ABL gene fusion which leads to uncontrolled growth of blood cells.