DNA (Double Strand) Antibody NcX DNA Serum in Ahmednagar
DNA (Double Strand) Antibody NcX DNA Serum test helps diagnose lupus
The anti-dsDNA test is used to check disease movement in a person who has been diagnosed with lupus. Those with lupus often have flare-ups in which symptoms worsen and then diminish. In particular, this test can be used to monitor lupus nephritis which is a critical complication of lupus that can damage the kidney and cause inflammation. Damage in the kidney can cause protein in the urine, high blood pressure, and kidney failure.
Your doctor may recommend this test for you if have been tested positive for ANA. The symptoms include:
- Extreme fatigue
- Joint pain
- Butterfly shaped rash on the nose
- Skin sensitivity to light
Anti-double stranded DNA antibody (anti-dsDNA) is one of the autoantibodies called ANA (antinuclear antibodies). Usually, antibodies protect against infection, but autoantibodies are produced when a person's immune system fails to sufficiently distinguish between "self" and "non-self." They wrongly attack the body's own healthy cells, causing tissue and organ damage. Anti-dsDNA specially targets the genetic material (DNA) found in the nucleus of a cell, hence the name "anti-dsDNA." The anti-dsDNA test identifies the presence of these autoantibodies in the blood.
While anti-dsDNA may be present in less quantities with a number of disorders, it is primarily associated with lupus. Lupus is a chronic inflammatory autoimmune disorder that can affect various tissues and/or organs of the body such as the kidneys, joints, blood vessels, skin, heart, lungs, and the brain. The test for anti-dsDNA, along with other autoantibody tests, also helps establish a diagnosis of lupus and distinguish it from other autoimmune disorders.
Reference Values Of DNA (Double Strand) Antibody NcX DNA Serum
Reference values apply to all ages.
<30.0 IU/mL (negative)
30.0-75.0 IU/mL (borderline)
>75.0 IU/mL (positive)
Negative is considered normal.
The results of an anti-dsDNA test are usually considered along with the person’s medical history and other tests.
- A high level of anti-dsDNA in the blood is strongly associated with lupus. When the anti-dsDNA is positive and the person tested shows signs of lupus, it means that the patient has lupus.
- A very low level of anti-dsDNA is considered negative but does not exclude the chances of lupus. Low to moderate levels of the autoantibody may be seen with other autoimmune disorders, such as Sjogren syndrome and mixed connective tissue disease (MCTD).
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Frequently Asked Questions
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