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AFB Drug susceptibility panel 1st and 2nd Line (10 drugs) by MGIT - Pure Culture
Also known as: AFB Drug Susceptibility Panel - 1st and 2nd Line (10 drugs), Pure Culture
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
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TB Drug Susceptibility Test Overview
The "AFB Drug susceptibility - 1st and 2nd Line (10 drugs) panel by MGIT - Pure Culture" test is a comprehensive and essential diagnostic tool for tuberculosis (TB) treatment. Using the MGIT (Mycobacteria Growth Indicator Tube) method on pure cultures of Mycobacterium tuberculosis (MTB) Complex, this test assesses the drug susceptibility of MTB to ten anti-tuberculosis drugs: Streptomycin, Isoniazid, Rifampicin, Ethambutol, Pyrazinamide, Kanamycin, Ethionamide, PAS (Para-AminoSalicylic Acid), Capreomycin, and Ofloxacin. The clinical utility of this test is vast as it provides critical information to healthcare professionals about the effectiveness of these drugs against the MTB Complex causing TB. By evaluating drug susceptibility to both first-line and second-line drugs, this test helps in the management of drug-sensitive and drug-resistant TB cases. The results enable clinicians to tailor personalized and effective treatment regimens, ensuring optimal care and increasing the chances of successful TB treatment. Overall, the AFB Drug susceptibility - 1st and 2nd Line (10 drugs) panel by MGIT is an indispensable tool in tuberculosis treatment, providing a comprehensive understanding of drug susceptibility patterns to guide targeted therapy. By enabling the selection of appropriate and effective drug combinations, this test significantly contributes to improved patient outcomes, better management of drug-resistant TB cases, and the overall fight against tuberculosis.
The AFB Drug Susceptibility Panel 1st and 2nd Line (10 drugs) by MGIT - Pure Culture is a comprehensive diagnostic test that evaluates the susceptibility of the Mycobacterium tuberculosis (MTB) complex to ten essential anti-tuberculosis drugs. This test utilises the Mycobacteria Growth Indicator Tube (MGIT) method on pure cultures of MTB, providing crucial insights into the effectiveness of various first-line and second-line drugs in treating tuberculosis. By assessing the susceptibility of MTB to drugs, this test enables doctors to develop personalised and effective treatment plans for patients with both drug-sensitive and drug-resistant tuberculosis.
The TB Drug Susceptibility Test plays a vital role in guiding the management of tuberculosis cases, as it helps identify the most appropriate drugs for each individual patient. By determining the susceptibility or resistance of the MTB strain to specific antibiotics, clinicians can tailor treatment regimens to maximise the chances of successful outcomes while minimising the risk of further drug resistance development.
Reasons for Undergoing the TB Drug Susceptibility Test
There are several reasons why a doctor may recommend the TB Drug Susceptibility Test:
- When a patient presents with symptoms suggestive of tuberculosis and requires an assessment of the effectiveness of various anti-tuberculosis drugs
- Following a diagnosis of tuberculosis, to guide the selection of the most appropriate treatment regimen based on drug susceptibility
- In cases where a patient has been undergoing anti-tuberculosis treatment but shows signs of treatment failure or persistent symptoms
- When there is a suspicion of drug-resistant tuberculosis, which necessitates the use of alternative or second-line drugs
- For patients with a history of non-compliance with tuberculosis treatment, to ensure that the chosen drugs will be effective against the specific strain of MTB
List of Parameters Considered During the TB Drug Susceptibility Test
The TB Drug Susceptibility Test assesses the susceptibility of MTB to ten essential anti-tuberculosis drugs:
- Streptomycin: An aminoglycoside antibiotic; resistance to this drug indicates the need for alternative treatment options
- Isoniazid: A key first-line antitubercular drug; resistance to isoniazid often requires the use of second-line drugs
- Rifampicin: A critical first-line drug; resistance to rifampicin is often a marker for multi-drug-resistant tuberculosis (MDR-TB)
- Ethambutol: A first-line drug used in combination therapy; resistance to ethambutol may necessitate changes in the treatment regimen
- Pyrazinamide: An essential first-line drug for treating tuberculosis; resistance to pyrazinamide can impact treatment outcomes
- Kanamycin: A second-line aminoglycoside antibiotic used in cases of drug-resistant tuberculosis
- Ethionamide: A second-line drug often used in combination regimens for drug-resistant tuberculosis
- Para-AminoSalicylic Acid (PAS): A second-line drug used in the treatment of drug-resistant tuberculosis
- Capreomycin: A second-line injectable drug used in cases of drug-resistant tuberculosis
- Ofloxacin: A fluoroquinolone antibiotic often used as a second-line drug for treating drug-resistant tuberculosis
TB Drug Susceptibility Test Preparation
To prepare for the TB Drug Susceptibility Test, consider the following:
- Inform Your Doctor: Let your doctor know about any medications, including antibiotics, that you are currently taking.
- Provide Medical History: Give your complete medical history and any previous tuberculosis treatment details to your doctor.
- Follow Specific Instructions: Adhere to any specific instructions given by your doctor, such as fasting requirements or discontinuing certain medications.
- Sample Collection: A trained professional will collect a sample of the MTB complex from your body, typically through a sputum sample or other bodily fluids.
TB Drug Susceptibility Test Results & Interpretation
The results of the TB Drug Susceptibility Test indicate the susceptibility or resistance of the MTB isolate to each of the ten tested drugs. The interpretation of the results is as follows:
- Susceptible: The MTB strain is likely to respond to the drug, and it can be included in the treatment regimen
- Resistant: The MTB strain is not likely to respond to the drug, and alternative drugs should be considered for treatment
- Intermediate: This result may indicate some level of resistance, and further testing or clinical judgment may be required to determine the appropriate course of action
These results are essential for clinicians to formulate personalised and effective treatment plans, particularly in cases of drug-resistant tuberculosis.
Home Collection for TB Drug Susceptibility Test
Metropolis Healthcare offers a convenient home sample collection service for the TB Drug Susceptibility Test. A trained phlebotomist will come to your doorstep to collect the necessary samples, ensuring your comfort and safety throughout the process. Metropolis Healthcare maintains high standards of sample handling and testing accuracy, ensuring that you receive timely and reliable results. By opting for home collection, you can benefit from Metropolis Healthcare's commitment to making healthcare accessible and providing quality diagnostic solutions conveniently at home.
AFB Drug Susceptibility Panel - 1st and 2nd Line (10 drugs), Pure Culture Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the AFB Drug Susceptibility Panel - 1st and 2nd Line (10 drugs), Pure Culture with a clear pricing structure.
The AFB Drug Susceptibility Panel - 1st and 2nd Line (10 drugs), Pure Culture Price in Mumbai is ₹ 10,070 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
This test measures the susceptibility of the MTB complex to ten different drugs used for treatment: Streptomycin, Isoniazid, Rifampicin, Ethambutol, Pyrazinamide, Kanamycin, Ethionamide, PAS, Capreomycin, and Ofloxacin.
• To guide the treatment of tuberculosis
• To determine which drugs will be effective in treating tuberculosis
• To assess drug resistance to tailor personalized treatment plans
• To ensure the appropriate use of medications to prevent drug resistance
This test is recommended • when a person has been diagnosed with tuberculosis to determine the most suitable medication regimen, • when there is a suspected case of drug-resistant tuberculosis, • prior to initiating tuberculosis treatment, especially in high-risk individuals, or • when monitoring treatment progress and assessing the need for treatment modifications.
Abnormal results may suggest drug resistance, requiring therapy modification.
During this test, a healthcare professional will collect a sample of the Mycobacterium tuberculosis (Mtb) complex from your body. They will send the sample for analysis using the MGIT (Mycobacteria Growth Indicator Tube) method.
• Inform your doctor of any medications, including antibiotics, you are currently taking. Also, tell them if you have any specific requirements.
• Provide your complete medical history and any previous tuberculosis treatment details.
• Follow any specific instructions given by your healthcare provider, such as fasting requirements or discontinuing certain medications.
• Acid-fast bacilli (AFB) smear test: This test helps detect the presence of acid-fast bacteria in sputum samples.
• GeneXpert MTB/RIF: This test helps detect tuberculosis and also identifies resistance to rifampicin, an important anti-tuberculosis medication.
TB drug susceptibility test
Tuberculosis (TB) is a contagious bacterial infection caused by the MTB complex. It primarily affects the lungs but can also affect other parts of the body.
The TB Drug Susceptibility Test is a diagnostic tool that determines the effectiveness of various anti-tuberculosis drugs against the Mycobacterium tuberculosis (MTB) complex. It is essential for managing both drug-sensitive and drug-resistant tuberculosis cases, enabling doctors to tailor personalised and effective treatment regimens.
Home sample collection is offered for TB Drug Susceptibility Test. In wich a trained phlebotomist will visit your home to collect the blood sample, ensuring that the sample is handled with the highest standards of care and accuracy.
The TB Drug Susceptibility Test doesn't measure "levels" but rather determines susceptibility or resistance to specific drugs. A susceptible result indicates the drug is effective, while a resistant result suggests the drug is not effective against the MTB complex.
The TB Drug Susceptibility Test determines which anti-tuberculosis drugs are effective against the specific strain of MTB infecting you. It helps in tailoring personalised treatment regimens, especially in cases of drug-resistant TB.
The TB Drug Susceptibility Test is typically performed when you are diagnosed with tuberculosis, show signs of treatment failure, or when there is a concern about drug-resistant TB.
The timing of the TB Drug Susceptibility Test is usually determined by your doctor based on your clinical condition and treatment needs. It is often performed at the beginning of treatment to guide the choice of drugs and may be repeated if there are signs of treatment failure or resistance.
Fasting is generally not required for the TB Drug Susceptibility Test. However, you should follow any specific instructions given by your doctor regarding medications or other preparations.
Before getting tested, patients should inform their doctor about any medications they're currently taking, provide a complete medical history, and follow any specific instructions given by their doctor.
The TB Drug Susceptibility Test assesses the susceptibility of MTB to ten drugs: streptomycin, isoniazid, rifampicin, ethambutol, pyrazinamide, kanamycin, ethionamide, para-aminosalicylic acid (PAS), capreomycin, and ofloxacin. The results indicate whether the bacteria are susceptible or resistant to each drug.
The TB Drug Susceptibility Test should be done when you are diagnosed with tuberculosis, exhibit symptoms of TB, have been on anti-tuberculosis treatment but show signs of treatment failure, or when there is a concern about drug-resistant tuberculosis.
The time required for the TB Drug Susceptibility Test can vary depending on the method used. The MGIT (Mycobacteria Growth Indicator Tube) method, which is a liquid culture-based technique, typically takes around 10–14 days to provide results.
The turnaround time for TB Drug Susceptibility Test reports can vary depending on the lab and the method used. Generally, you can expect to receive the reports within 4 weeks based on the day/time when the sample was collected and processed.
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