PRA identification Class I and Class II

PRA Identification by Luminex is a test that assesses the presence and strength of antibodies in a recipient's blood against specific human leukocyte antigens (HLA) in both Class I and Class II. The Class I component evaluates the recipient's immune response to Class I HLA antigens, which are expressed on most nucleated cells, while the Class II component focuses on Class II HLA antigens primarily found on immune cells. By analyzing the recipient's antibody-antigen interactions using Luminex technology, the test provides valuable information about the level of sensitization and compatibility between the recipient and potential organ or tissue donors. Higher PRA levels in either Class I or Class II indicate a higher likelihood of pre-existing antibodies that may lead to immune-related complications following transplantation. This information aids transplant teams in making informed decisions regarding donor selection, cross-matching, and the development of personalized immunosuppressive strategies to minimize the risk of rejection and optimize transplant outcomes.