PR3 by EIAc-ANCA Serum Test

PR3 ANCA Test Overview

PR3-c-ANCA (proteinase 3-cytoplasmic antineutrophil cytoplasmic antibody) serum is a blood test that measures the presence of antibodies against a specific protein called proteinase 3 (PR3). PR3 is found in neutrophils, which are a type of white blood cell that plays an important role in the immune system. In the case of PR3-c-ANCA, these antibodies target and bind to PR3, causing damage to the neutrophils and leading to inflammation in the affected tissues. PR3-c-ANCA testing is commonly used in the diagnosis of certain autoimmune diseases, such as granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis. In addition to GPA, PR3-c-ANCA testing may also be used to diagnose other forms of vasculitis (inflammation of blood vessels) and autoimmune disorders that involve the immune system attacking the body's own tissues.

The PR3 ANCA test, also known as the PR3 blood test or PR3 lab test, is a diagnostic tool used to detect the presence of autoantibodies against the proteinase 3 (PR3) enzyme in the blood. These autoantibodies are associated with various autoimmune disorders, particularly those involving systemic vasculitis, such as Granulomatosis with Polyangiitis (GPA), Microscopic Polyangitis (MPA), and Eosinophilic Granulomatosis with Polyangiitis (EGPA).

Written By: Supriya Kulkarni, Lead-Content & Training

Reviewed By: Dr. Alap Christry M.D. AVP-Lab Operations & Scientific Business Head-Clinical Chemistry