Maturity - Onset Diabetes - Young (MODY) & Neonatal Diabetes Gene Panel by NGS, EDTA Blood**

What Is the MODY (Maturity-Onset Diabetes of the Young) Gene Panel?

The MODY Gene Panel is a genetic blood test that helps identify inherited causes of diabetes that appear early in life. MODY and neonatal diabetes are caused by changes in a single gene and are different from the more common types of diabetes.

This test uses a blood sample to analyse multiple diabetes-related genes at the same time. It helps your doctor confirm whether diabetes is genetic, allowing treatment to be tailored more accurately to your condition.

What Does the MODY (Maturity-Onset Diabetes of the Young) Gene Panel Measure?

This test examines specific genes known to be associated with monogenic diabetes:

• Detection of disease-causing variants linked to MODY and neonatal diabetes
• Differentiation between genetic diabetes and type 1 or type 2 diabetes
• Guidance for personalised treatment choices, including non-insulin therapies in some cases
• Assessment of inherited risk for close family members

MODY (Maturity-Onset Diabetes of the Young) Gene Panel: Who Needs It and Why It’s Done

What Symptoms May Call for a MODY (Maturity-Onset Diabetes of the Young) Gene Panel?

Doctors may recommend this test if diabetes shows atypical features, such as:

• Diabetes diagnosed at a young age, often before 25 years
• Mild or stable high blood sugar levels
• Diabetes controlled without insulin for long periods
• Strong family history of diabetes across generations
• Lack of features typical of type 1 or type 2 diabetes

Who Should Get a MODY (Maturity-Onset Diabetes of the Young) Gene Panel?

• Children or young adults diagnosed with diabetes early in life
• Individuals with diabetes and a clear family history
• Infants diagnosed with diabetes within the first six months of life
• Patients whose diabetes type remains unclear
• Family members of a person diagnosed with MODY

Why Is a MODY (Maturity-Onset Diabetes of the Young) Gene Panel Done?

• The test confirms whether diabetes has a genetic cause, helping your doctor select the most effective treatment and avoid unnecessary therapies.

Importance of the MODY (Maturity-Onset Diabetes of the Young) Gene Panel

• Identifying MODY is important because treatment and long-term care can differ significantly from other forms of diabetes.
• Some MODY types respond well to oral medicines rather than insulin.
• A confirmed genetic diagnosis also supports family screening, long-term planning, and genetic counselling.

MODY (Maturity-Onset Diabetes of the Young) Gene Panel Booking & Reports – Metropolis Healthcare

How to Book the MODY (Maturity-Onset Diabetes of the Young) Gene Panel and Get Your Reports?

1. Simple Online Booking
   Booking can be done through the Metropolis Healthcare App or website. Select the MODY (Maturity-Onset Diabetes of the Young) Gene Panel, choose a convenient time slot, and provide your address for a blood test at home. You may also visit a nearby Metropolis Lab if you prefer in person sample collection.
2. Safe Home Sample Collection
   Trained phlebotomists collect your blood sample while strictly following safety and hygiene protocols.
3. Sample Tracking Updates
   You receive updates at every stage, from sample collection to testing, through the Metropolis Healthcare platform.
4. Accurate Laboratory Testing
   Your sample is processed at NABL and CAP accredited laboratories using advanced next generation sequencing technology.
5. Quick and Easy Reports
   Your reports are shared via email, WhatsApp, or can be downloaded from the Metropolis Healthcare website or app.

Is Home Sample Collection for MODY (Maturity-Onset Diabetes of the Young) Gene Panel Available Near You?

Yes, Metropolis Healthcare offers home sample collection for the MODY (Maturity-Onset Diabetes of the Young) Gene Panel. This service saves you time, reduces the need for travel, and ensures professional sample handling while maintaining strict quality standards.

In How Much Time Will I Get the MODY (Maturity-Onset Diabetes of the Young) Gene Panel Report?

Reports are usually available in around 4 weeks once the sample reaches the lab.
Note: Reporting time may vary based on your location.

Where Can I See or Get MODY (Maturity-Onset Diabetes of the Young) Gene Panel Results?

You can view and download your reports through the Metropolis Healthcare website or app. Reports are also sent via email or WhatsApp, and you may collect a physical copy from the Metropolis Lab if required.

Interpreting MODY (Maturity-Onset Diabetes of the Young) Gene Panel Results

What Your MODY (Maturity-Onset Diabetes of the Young) Gene Panel Results May Indicate

How Should You Prepare for a MODY (Maturity-Onset Diabetes of the Young) Gene Panel?

This test requires minimal preparation from you:

• No fasting required: You can eat and drink normally
• Continue medications: Do not stop diabetes medicines unless advised by your doctor
• Inform your doctor: Share your diabetes history and family medical history
• Complete forms: Ensure the test requisition form and genetic history details are filled in
• Normal hydration: Drink water as you usually would before the blood draw

How Is a MODY (Maturity-Onset Diabetes of the Young) Gene Panel Done? (Step-by-Step Procedure)

The MODY Gene Panel is performed using a simple blood collection process:

• Preparation: A tourniquet is tied around your arm to make veins more visible
• Cleaning: The puncture site is cleaned with antiseptic
• Sample Collection: About 3 to 5 ml of blood is drawn into an EDTA vacutainer using a sterile needle
• Completion: The needle is removed, and a bandage is applied
• Processing: The sample is analysed using next generation sequencing to detect genetic variants

Conditions That May Affect MODY (Maturity-Onset Diabetes of the Young) Gene Panel Accuracy

Certain patient-related factors may influence result interpretation:

• Incomplete clinical or family history details
• Recent blood transfusion
• Complex inheritance patterns within families
• Limited correlation with clinical presentation

Diseases That the MODY (Maturity-Onset Diabetes of the Young) Gene Panel Can Help Detect

• Maturity-onset diabetes of the young
• Neonatal diabetes mellitus
• Monogenic diabetes disorders
• Inherited insulin secretion defects
• Genetic insulin resistance conditions

References

1. Fajans S.S., Bell G.I., Polonsky K.S. (2001). Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. New England Journal of Medicine, 345(13), 971–980. PMID: 11575287
2. Hattersley A.T., Patel K.A. (2017). Precision diabetes: Learning from monogenic diabetes. Diabetologia, 60(5), 769–777. PMID: 28224262
3. Shepherd M., Shields B., Ellard S., Rubio-Cabezas O., Hattersley A.T. (2009). A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of patients. Diabetologia, 52(4), 567–570. PMID: 19142686
4. Pearson E.R., Starkey B.J., Powell R.J., Gribble F.M., Clark P.M., Hattersley A.T. (2003). Genetic cause of hyperglycaemia and response to treatment in diabetes. Lancet, 362(9392), 1275–1281. PMID: 14575971