Array Chrome - Chromosomal Microarray Test

Chromosomal Array, Comparative genomic hybridization (CGH) Chromosome array test is a test to identify genetic causes of developmental delay in children.  In addition a genetic counselling is provided to parents of the affected child

Overview

The chromosomal array is a laboratory test that can be used to detect genetic abnormalities in an individual. It is a powerful tool that can help diagnose and monitor genetic conditions, both inherited and acquired. Comparative genomic hybridization (CGH) is a test to identify genetic causes of developmental delay in children. In addition, genetic counseling is provided to the parents of the affected child.

What is a chromosomal array?

Chromosomal array analysis involves the use of specialized technology to look at an individual’s entire genome sequence. The analysis provides comprehensive information on abnormal chromosomal changes, including deletions, duplications, and rearrangements of pieces of chromosomes. These data can provide important insights into the underlying cause of a person’s health condition or disorder.

The advantages of chromosomal array testing over traditional testing methods are numerous. For one, it has a higher resolution than traditional methods such as karyotyping or fluorescent in situ hybridization (FISH). In addition, chromosomal array testing is more cost-effective because of its ability to detect multiple types of genetic abnormalities simultaneously. Finally, results from chromosomal array testing can be obtained more quickly than traditional methods because it requires fewer steps in the laboratory process.

Who should get the chromosomal array test done?

• Individuals who have a family history of chromosomal disorders or genetic syndromes.
• Individuals with unexplained multiple miscarriages, stillbirths, or other pregnancy loss.
• Infants or children with developmental delays, growth delays, or physical abnormalities.
• Infants or children with a history of a birth defect or congenital abnormality.
• Individuals with a history of learning difficulties.
• Couples undergoing in vitro fertilization (IVF).

Written by: Dr Vishal Wadhwa, M.D, D.N.B Microbiology, Medical Affairs