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Endomysial Antibody EMA IgA Serum Test

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Anti-endomysial antibodies (EMA) -— antibodies developed in reaction to the ongoing damage to the intestinal lining; it has been found that tTg is the substance detected in this test.

Endomysial Antibody IgA (EMA IgA) is a type of antibody that can be detected in the blood serum of individuals with celiac disease. Celiac disease is an autoimmune disorder that is triggered by the ingestion of gluten, a protein found in wheat, rye, and barley.

EMA IgA antibodies target the endomysium, which is a layer of connective tissue that surrounds muscle fibers. When gluten is ingested, the body's immune system can mistakenly attack the endomysium in addition to attacking the gluten, resulting in damage to the small intestine and other parts of the body.

EMA IgA antibodies are a highly specific and sensitive marker of celiac disease, with a reported sensitivity of up to 98% and a specificity of up to 100%.

Associated Tests:

E0028    Endomysial Antibody IgG antibody Serum

C0285    Coeliac disease profile-2 Comprehensive

C0079    Celiac Disease Profile

C0284    Coeliac Disease Profile-1

T0133    tTG Antibody-IgA Tissue Transglutaminase,Celiac disease Serum

T0134    tTG Antibody-IgG Tissue Transglutaminase,Celiac disease Serum

G0022   Gliadin-IgA Antibodies De-amidated (DGP)Serum

G0023   Gliadin-IgG Antibodies De-amidated (DGP)Serum


Written by: Supriya Kulkarni, Lead-Content & Training



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Endomysial Antibody EMA IgA Serum Test Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Endomysial Antibody EMA IgA Serum Test with a clear pricing structure.

The Endomysial Antibody EMA IgA Serum Test Price in Mumbai is ₹ 2,390 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

Test helps in detection of IgA-endomysial antibodies for the diagnosis of dermatitis herpetiformis and celiac disease Monitoring adherence to gluten-free diet

Test is done on patient suffering from suspected Celiac disease

Almost 100% of people with active celiac disease and 70% of those with dermatitis herpetiformis (another gluten-sensitive condition that causes an itchy, burning, blistering rash on the skin) will have the IgA class of anti-EMA antibodies.

  • The Endomysial Antibody IgA antibody Serum Test is used for
  • confirmation of coeliac disesase in patients who are positive for tTG IgA.
  • EMA IgA antibodies can also be used to monitor adherence to a gluten-free diet, as levels of the antibody typically decrease in response to the elimination of gluten from the diet.


The Endomysial Antibody IgA (EMA IgA) serum test measures the presence and levels of EMA IgA antibodies in the blood.

If EMA IgA antibodies are present in high levels, it is strongly indicative of celiac disease.

The test involves drawing a small amount of blood from a vein in your arm. A healthcare professional will clean the area with an antiseptic, wrap an elastic band around your upper arm to make the veins more visible, and insert a needle into a vein to collect the blood sample. You may feel a brief prick or stinging sensation when the needle is inserted, but the procedure is generally painless

No special preparation is required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status.


Some common symptoms that may warrant testing for celiac disease with the EMA IgA serum test include:

  • Gastrointestinal symptoms: Abdominal pain, bloating, gas, diarrhea, constipation, and nausea are common gastrointestinal symptoms associated with celiac disease.
  • Malabsorption and malnutrition: Celiac disease can lead to malabsorption of nutrients, which can result in malnutrition, weight loss, and fatigue.
  • Skin rash: A skin rash called dermatitis herpetiformis can occur in individuals with celiac disease, and may warrant testing for the condition.
  • Joint pain: Joint pain and inflammation are also common in individuals with celiac disease.
  • Unexplained iron deficiency anemia: Celiac disease can cause iron deficiency anemia that does not respond to iron supplements.

Delayed growth and puberty: Children with celiac disease may experience delayed growth and puberty due to malnutrition

There are several other blood tests that may be ordered in conjunction with the Endomysial Antibody IgA (EMA IgA) serum test to screen for and diagnose celiac disease. These tests may include:

  • Tissue transglutaminase antibodies (tTG IgA and tTG IgG): These tests measure the presence and levels of antibodies that target tissue transglutaminase, an enzyme that is important in the development of celiac disease. Like the EMA IgA test, these tests are highly specific and sensitive for celiac disease.
  • Deamidated gliadin peptide antibodies (DGP IgA and DGP IgG): These tests measure the presence and levels of antibodies that target deamidated gliadin peptides, a component of gluten. These tests are useful in cases where the EMA IgA and tTG IgA tests are negative, but celiac disease is still suspected.
  • Total serum IgA: This test measures the total amount of immunoglobulin A (IgA) in the blood. This test is important because a small percentage of individuals with celiac disease may have a deficiency in IgA, which can cause false negative results on the EMA IgA and tTG IgA tests.
  • Biopsy: In some cases, a biopsy of the small intestine may be performed to confirm the diagnosis of celiac disease.

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