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MAMMATYPER

Innovation in breast cancer diagnosis

Molecular in vitro diagnostic test for the quantitative detection of the mRNA expression of ERBB2, ESR1, PGR and MKI67 in breast cancer tissue

Overview

Breast Cancer

Breast cancer is the most common cancer worldwide including India, with one in eight women diagnosed with the disease during their lifetime and more than 464,000 new cases diagnosed in 2012 alone. (29% of female cases and 13% of the total cancer cases).

About MammaTyper

Innovation in breast cancer diagnosis

Molecular in vitro diagnostic test for the quantitative detection of the mRNA expression of ERBB2, ESR1, PGR and MKI67 in breast cancer tissue

Diagnosis

To identify potential cancers as early as possible specific screening procedures are available and promoted through screening programs such as:

  • Breast Physical Examination
  • Breast Self-Examination
  • CT Scans (Computerized Tomography)
  • Chest X-Rays
  • Ultrasound

Molecular Subtypes

The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel recommends the use of four biomarkers for molecular subtyping of breast cancer:

  • ERBB2 (HER2, human epidermal growth factor receptor 2)
  • ESR1 (estrogen receptor 1)
  • PGR (progesterone receptor)
  • MKI67 (marker of proliferation Ki-67, a marker expressed in proliferating cells)

Biomarker

ERBB2 is the name of the gene for human epidermal growth factor receptor 2 (HER2). This receptor is a cell surface protein which belongs to the family of epidermal growth factor receptors. ERBB2 activation stimulates cell proliferation and inhibits programmed cell death. ERBB2 has an important role in breast cancer. About 20 % of all breast cancers show an overexpression of this receptor, which is associated with poor prognosis and clinical outcome.

Therapy

In recent years numerous life-saving treatment options have been developed for the therapy of breast cancer. Today there is a wide selection of treatments available to fight each individual breast cancer type. For a personalized treatment recommendation different approaches are selected and combined based on a sound diagnosis.

FAQs for Patients

My Mammography result showed abnormalities. What is the next step?

You may require to undertake take a biopsy sample of your breast tissue as guided by your clinician.

FAQs for Oncologists

Here Is A Guide For You To Know In Details About The Services Offered By Our Laboratory.

The FAQ section is a ready reckoner for any and all queries that you may have. In case, you still have further questions, feel free to write in to us!

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