Vdrl Test

RPR is done to screen presence of Syphilis in people with high risk of contracting infection & as a part of screening panel for all pregnant women (to prevent congenital infections). 
RPR is a semi-quantitative assay and it helps in monitoring progression of disease and also to assess response to treatment.

RPR detects nonspecific antibodies (Both IgM& IgG) in blood which are produced in response to lipoidal material released from damaged patient cells.

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

A negative result means patient is not suffering from syphilis.
A positive test with titre >= 1:8 is conidered significant which may indicate ongoing or recent infection.
Diagnosis should be confirmed by TPHA (Treponemal test). 
Reactive titre< 1:8 is often associated with biological false positives which may occure during pregnancy, alcohol consumption and in conditions like malaria, hepatitis, mumps, Leprosy, infectious mononucleosis, collagen tissue diseases  
Demonstrating a four fold rise in titre in paired sample is more meaningful than single estimate