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Protein C Activity Functional Citrated plasma Test
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
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Accurate & Quality Test Reports
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Protein C Activity Functional Citrated plasma Test Details in Brief
| Also Known As | Protein C Functional Activity Test, Protein C Function Test |
|---|---|
| Purpose | Assesses Protein C function to diagnose clotting disorders and risk of thrombosis |
| Preparation | Inform your doctor about all medications, especially anticoagulants like warfarin or heparin |
| Fasting | Fasting not required |
| Reporting Time | Next Day |
| Cost | 4,500 |
What is a Protein C Activity Test?
The Protein C Activity Test is a blood test that measures how effectively the Protein C in your blood prevents excessive clotting. Protein C is a natural anticoagulant protein produced by the liver. It works with Protein S to deactivate certain clotting factors (Factor Va and VIIIa), helping maintain normal blood flow.
This test evaluates the functionality (activity) of Protein C rather than just its quantity, helping detect inherited or acquired Protein C deficiencies. Such deficiencies can increase the risk of blood clots (thrombosis) in veins, including deep vein thrombosis (DVT), pulmonary embolism (PE), and other clotting complications.
The test requires a plasma sample collected in a sodium citrate tube.
What Does a Protein C Activity Test Measure?
The Protein C Activity Test helps assess your body’s natural ability to prevent abnormal clot formation:
- Protein C Function: Measures how efficiently Protein C inactivates clotting factors to prevent excess clotting.
- Clotting Regulation: Evaluates the balance between clot formation and breakdown in your bloodstream.
- Anticoagulant Response: Helps understand the effect of certain anticoagulant therapies on your body.
- Deficiency Detection: Identifies inherited or acquired Protein C deficiencies that can lead to recurrent blood clots.
- Pregnancy and Surgery Risk Assessment: Used to evaluate clotting risk before surgery or during pregnancy in women with a history of miscarriage or thrombosis.
Protein C Activity Test: Who Needs It and Why It’s Done
What Symptoms May Call for a Protein C Activity Test?
You may need this test if you experience:
- Unexplained or recurrent blood clots (DVT or PE)
- Swelling, redness, or pain in the legs due to blocked veins
- Shortness of breath or chest pain caused by clot migration to the lungs
- Recurrent miscarriages or pregnancy complications
- Unusual clotting after surgery or trauma
Who Should Get a Protein C Activity Test?
Doctors recommend this test for:
- Individuals with a family history of Protein C deficiency or thrombophilia
- Patients with unexplained blood clots before the age of 50
- Women with repeated miscarriages or clotting issues during pregnancy
- Newborns showing signs of severe clotting conditions like purpura fulminans
- Patients on anticoagulant therapy needing monitoring or reassessment
Why is a Protein C Activity Test Done?
The Protein C Activity Test is done to determine if your blood’s natural anticoagulant mechanism is functioning properly. It helps doctors diagnose Protein C deficiency, understand your clotting risk, and decide on appropriate treatment or preventive measures.
Importance of a Protein C Activity Test
This test plays a vital role in diagnosing and managing clotting disorders. Low Protein C activity can lead to serious and life-threatening conditions like deep vein thrombosis, pulmonary embolism, or pregnancy complications.
By identifying Protein C deficiency early, your doctor can recommend timely treatment to prevent clot formation, especially before surgery, during pregnancy, or when starting certain medications.
Protein C Activity Test Booking & Reports – Metropolis Healthcare
How to Book the Protein C Activity Test and Get Your Reports
- Simple Online Booking
Book your Protein C Activity Test on the Metropolis Healthcare website or app. Choose a convenient slot for home sample collection or visit the nearest Metropolis lab. - Safe Home Sample Collection
Our trained technicians collect your blood sample safely, following all hygiene protocols. - Sample Tracking Updates
Stay updated on your sample status through the Metropolis Healthcare website or app. - Accurate Laboratory Testing
The test is performed using a Chromogenic Assay in NABL & CAP-accredited labs to ensure precise results. - Quick & Easy Reports
Access your test results easily via email, WhatsApp, or by logging in to the Metropolis website or app.
Is Home Sample Collection for Protein C Activity Test Available Near You?
Yes. Metropolis Healthcare offers convenient home collection services for the Protein C Activity Test. Trained phlebotomists visit your home to collect your blood sample safely, ensuring comfort and convenience for patients with mobility concerns or post-surgical recovery.
How Long Does It Take to Get a Protein C Activity Test Report?
Reports are usually available within 1 day after the sample reaches the laboratory.
Note: Reporting time may vary depending on your location.
Where Can I See or Get Protein C Activity Test Results?
You can access your test reports via the Metropolis Healthcare website or app, where you can view or download them securely. Reports are also sent through email or WhatsApp, and printed copies can be collected from your nearest lab.
Interpreting Protein C Activity Test Results
What Your Protein C Activity Test Results May Indicate
|
Parameter |
Normal Range |
Low Values May Indicate |
High Values May Indicate |
|
Protein C Activity |
70–130% (Non-pregnant adults) Pregnancy: 67–135% (varies by trimester) |
Inherited or acquired Protein C deficiency, liver disease, Vitamin K deficiency, DIC, or warfarin therapy |
Possible heparin therapy interference or increased Factor VIII levels |
Understanding Abnormal Protein C Activity Test Results by Parameter
|
Parameter |
Low Results May Indicate |
Remarks |
|
Protein C Activity |
Protein C deficiency (genetic or acquired), liver dysfunction, or Vitamin K deficiency |
May cause recurrent thrombosis or pregnancy complications |
|
Protein C Activity |
Decreased levels due to oral anticoagulants (warfarin) |
Re-testing recommended after stopping medication for accurate measurement |
|
Protein C Activity |
Abnormal function despite normal Protein C levels |
Indicates dysfunctional Protein C molecule (Type II deficiency) |
How Should You Prepare for a Protein C Activity Test?
Follow these steps for accurate results:
- No fasting required: You can eat and drink as usual before the test.
- Medication review: Inform your doctor if you are taking anticoagulants (like warfarin, heparin) or birth control pills.
- Pause anticoagulants if advised: Warfarin may lower Protein C levels; your doctor might suggest stopping it for up to 2 weeks before testing.
- Avoid recent transfusion: Blood transfusions can temporarily affect Protein C results.
- Provide medical history: Share any recent surgeries, liver disease, or pregnancy details with your healthcare provider.
How Is a Protein C Activity Test Done? (Step-by-Step Procedure)
- Preparation: A tourniquet is tied around your upper arm to make veins more visible.
- Cleaning: The puncture site is cleaned with antiseptic.
- Sample Collection: A sterile needle is inserted into your vein, and about 1 ml of blood is drawn into a sodium citrate vacutainer.
- Processing: The sample is processed to obtain plasma, which is tested using a chromogenic assay to measure Protein C activity.
- Completion: The puncture site is covered with a small bandage, and the sample is frozen and transported to the lab for analysis.
Conditions That May Affect Protein C Activity Test Accuracy
Several factors can influence test accuracy:
- Recent anticoagulant therapy (warfarin or heparin) may alter results.
- Pregnancy and hormonal therapy can affect Protein C activity levels.
- Liver disease or Vitamin K deficiency may cause low Protein C levels.
- Acute infection, surgery, or trauma can temporarily change clotting factor levels.
- Blood transfusions within 2 weeks before the test may interfere with results.
Diseases That a Protein C Activity Test Can Help Detect
The test helps diagnose and monitor:
- Inherited Protein C deficiency
- Deep Vein Thrombosis (DVT)
- Pulmonary Embolism (PE)
- Recurrent pregnancy loss due to clotting disorders
- Disseminated Intravascular Coagulation (DIC)
- Liver disease-related clotting abnormalities
- Purpura Fulminans in newborns
Protein C Activity Test Price in Different Cities
The cost of a Protein C Activity Test may vary depending on your location. Here's a table showing the approximate price range for the Protein C Activity Test at Metropolis Healthcare in major Indian cities:
|
City |
Approximate Cost (INR) |
|
₹ 4350 to ₹ 4750 |
|
|
₹ 4350 to ₹ 4750 |
|
|
₹ 4350 to ₹ 4750 |
|
|
₹ 4350 to ₹ 4750 |
The Protein C Activity Test cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive Protein C Activity Test prices across major cities in India.
References
- Dahlbäck B. (2000). The protein C anticoagulant system: inherited defects as basis for venous thrombosis. Thrombosis Research, 98(1), V49–V54. PMID: 10708818
- Esmon C.T. (2009). The roles of Protein C and thrombomodulin in the regulation of blood coagulation. Journal of Biological Chemistry, 284(44), 24074–24078. PMID: 19679641
- Griffin J.H., Zlokovic B.V., Mosnier L.O. (2012). Protein C anticoagulant and cytoprotective pathways. Nature Medicine, 18(4), 463–474. PMID: 22481499
- DiScipio R.G., et al. (1995). Functional assays for Protein C activity in plasma. Clinical Chemistry, 41(8), 1200–1206. PMID: 7628082
- Tait R.C., Walker I.D., et al. (1995). Inherited Protein C deficiency and venous thrombosis. Blood, 85(2), 551–555. PMID: 7811999
Protein C Activity Functional Citrated plasma Test Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Protein C Activity Functional Citrated plasma Test with a clear pricing structure.
The Protein C Activity Functional Citrated plasma Test Price in Mumbai is ₹ 4,500 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
It measures how effectively your Protein C functions to prevent abnormal blood clots.
Fasting is not required; you can eat and drink normally.
Yes, anticoagulants like warfarin or heparin and hormonal treatments can alter test results.
It may indicate Protein C deficiency, liver disease, Vitamin K deficiency, or the effect of anticoagulant use.
A blood sample is drawn into a sodium citrate tube, and plasma is tested using a chromogenic assay.
If you were on anticoagulant medication during the first test, your doctor may repeat it after discontinuation for accuracy.
Is the test done during pregnancy.
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