Parietal Cell Antibody GPCA Test By IFA Serum

This test is done to establish the cause of Vitamin B12 deficiency. Vitamin B12 deficiency can occur due to dietary imbalance, Intrinsic factor antibody or parietal cell antibody. Establishing the cause of deficiency can help guide appropriate treatment

The GPCA test is typically done for several reasons, including:

• To diagnose autoimmune disorders such as pernicious anemia
• To monitor treatment response in patients with autoimmune disorders
• To screen for gastric cancer
• To differentiate between autoimmune and infectious causes of atrophic gastritisA GPCA is typically done to help diagnose autoimmune conditions such as pernicious anemia and gastritis. These can cause damage to the parietal cells.

This test measures antibodies against parietal cells which in turn produce Intrinsic factors. This factor helps in the absorption of vitamin B12

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in a vacutainer

Absence of antibodies against parietal cells rules out this as a cause of Vitamin B12 deficiency.
The presence of antibodies against parietal cells confirms the cause of vitamin B12 deficiency. This may coexist with intrinsic factor antibody also

Parietal cells are specialized cells. They are found in the stomach. They are responsible for making gastric acid. Antibodies against parietal cells are antibodies that target these cells. The immune system makes these antibodies. It does this in response to an autoimmune disease like pernicious anemia.

Autoimmune disorders are conditions in which the body's immune system mistakenly attacks and destroys its own cells. In the case of pernicious anemia, the immune system attacks and destroys the parietal cells of the stomach. This leads to a decrease in gastric acid production. This can lead to a number of symptoms such as anemia, stomach pain, indigestion, and weight loss.

A parietal cell antibody test is a blood test. It is used to detect the presence of antibodies in the parietal cells in the stomach. These cells produce hydrochloric acid (HCl). HCl is necessary for the proper digestion of food.

A GPCA test is performed by taking a blood sample from the patient. It is then sent to a laboratory for analysis.

A positive result on a GPCA test indicates the presence of antibodies in the parietal cells. It can suggest the presence of an autoimmune condition. A negative result, on the other hand, typically indicates no autoimmune disease or gastritis.

A GPCA test is a relatively simple and safe procedure with minimal risks or complications. The most common risks associated with a blood test, such as bleeding or infection, are present.

Certain medications, such as proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs), can affect the results of a parietal cell antibody test. It's important to inform your doctor if you are taking any medications before your test.

If you have a positive result on a GPCA test, it is important to follow up with your healthcare provider to further evaluate your condition and develop a treatment plan.

IFA Serum stands for Indirect Immunofluorescence Assay. It is a lab test. It uses fluorescent dyes to detect antibodies in a blood sample.

In the IFA Serum test, a small sample of blood is taken from the patient. It is placed on a microscope slide that has been coated with stomach cells. The blood sample is then examined under a microscope to see if the antibodies are present.

A positive GPCA test result indicates that the person has antibodies against the cells in the stomach that produce acid. This can be a sign of pernicious anemia or other autoimmune conditions.

A negative GPCA test result indicates that the person does not have antibodies against the cells in the stomach that produce acid.

• Patients with Vitamin B12 deficiency
• Patients with symptoms of macrocytic anemia, such as fatigue or weakness
• Patients with symptoms of gastric problems, such as stomach pain or indigestion
• Patients with a family history of autoimmune disorders
• Patients with a history of gastric cancer

• PCA Test
• Parietal Cell Ab, IgG, S
• GPCA Test
• Parietal Cell Antibody (PCA) Test
• Gastric Parietal Cell Antibody Test
• Anti-Parietal Cell Antibody Test

• Vitamin B12 and Folate Levels • Intrinsic Factor Antibody Test • Gastric Acid Output Test • Endoscopy with Biopsy • Anti-Intrinsic Factor Test