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NMO With MOG Antibody Profile, Serum
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Blood
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Male, Female
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Within 24 Hours
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Overview
Neuromyelitis Optica is an inflammatory autoimmune disease causing demyelination of the central nervous system with degradation of the insulating sheath of at least one optical nerve (Neuritis nervi optici) and at the same time or few months later the spinal cord (Myelitis).
Symptoms of autoimmune disorders are brought on when the body erroneously attacks healthy cells. Antibodies carry out these assaults. Our immune system produces these antibodies, which are nothing but proteins specifically designed to prevent pathogens from harming humans. They can attack a variety of bacteria, viruses, and other organisms. Antibodies are vital to the defence mechanisms of our immune system. These antibodies might, however, make errors from time to time. They accidentally target normal healthy cells rather than pathogens and are known as autoantibodies. Depending on whether normal tissue was assaulted, this could result in harm and several problems. A condition of the central nervous system called Neuromyelitis Optica (NMO) is one such autoimmune disease. Here's all you need to know about NMO and the NMO with MOG antibody profile.
What is NMO?
NMO primarily affects the spinal cord (myelitis) and eye nerves (optic neuritis). The precise mechanism through which NMO arises is unknown; it is assumed to be connected to a problem with the blood-brain barrier, which permits auto-antibodies to penetrate the brain and spinal cord and harm and inflame certain cells. The myelin sheath of the brain's nerves is one region that is damaged. Although the autoimmune condition cannot be healed, the patient can have an active life with proper treatment. Since multiple sclerosis, another autoimmune illness can have comparable symptoms but advance in a different way, it is important to distinguish between the two. In incidences of NMO and NMOSD (NMO spectral disorders), respectively, the NMO antibody and MOG antibodies are positive. The NMO with MOG antibody profile test is done to diagnose and evaluate these conditions.
Who should do the NMO With MOG Antibody Profile test?
People with one or more of the following symptoms should do this test -
- A weakened back and arms.
- Tight, uncomfortable spasms in the arms and legs.
- Discomfort in the arms and legs.
- Heightened reactivity to cold and heat.
Problems with the bladder, bowels, and sexuality
Why is the NMO With MOG Antibody Profile test done?
This examination looks for NMO and MOG antibodies. The presence of NMO & MOG antibodies is diagnostic of NMO and related spectral disorders. 80% of NMO patients test positive for NMO antibodies while 20% of patients may test negative, but will test positive for MOG antibodies. This test helps to diagnose and distinguish this disorder from multiple sclerosis.
Written by: Dr Vishal Wadhwa, M.D, D.N.B Microbiology, Medical Affairs
NMO With MOG Antibody Profile, Serum Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the NMO With MOG Antibody Profile, Serum with a clear pricing structure.
The NMO With MOG Antibody Profile, Serum Price in Mumbai is ₹ 6,800 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
For Differential diagnosis of NMO from Multiple sclerosis Highly specific serum autoantibody markers are found very frequently in NMO, while they are not detected in Multiple sclerosis (MS) or healthy subjects.
Performed for patients suspected to be suffering from Neuromyelitis optica
Neuromyelitis Optica is an inflammatory autoimmune disease causing demyelination of the central nervous system with degradation of the insulating sheath of at least one optical nerve (Neuritis nervi optici) and at the same time or few months later the spinal cord (Myelitis). NMO AQP4-Ab -are disease specific auto Ab, found in in 70-80% NMO Patients. MOG Antibodies are present in 20% of AQP4 –Seronegative patients with a phenotype of NMOSD (neuromyelitis optica spectrum disorder) MOG antibodies are found in Patients positive for MOG-IgG have a high risk of recurrent disease course
NMO and MOG antibodies are measured by this test.
People who have at least one of the following symptoms ought to take this test:
- Feeble arms and back.
- Leg and arm spasms that are painful and tight.
- Discomfort in arms and legs.
- Increased sensitivity to heat and cold.
- Issues with the bowels, the bladder, and sexuality.
If you experience one or more of the above symptoms that have no explanation, you should immediately consult your doctor. Your doctor may then recommend you take this test to check for NMO.
This test may be recommended by the doctor to identify NMOSD and distinguish it from conditions like multiple sclerosis, longitudinal extensive spinal cord lesions, autoimmune encephalitis, etc. This test also aids in tracking the prognosis and likelihood of NMOSD relapse. The progression of the illness and the effectiveness of the treatment may also be tracked.
For this test, a tourniquet (elastic band) is tightly applied to the upper arm to collect a blood sample. A fist is then requested from the patient. This aids in filling up veins with blood. Before inserting the needle, the skin is cleaned, and a vacutainer is used to collect the drawn blood sample. Your doctor will need to collect cerebrospinal fluid (CSF) through a lumbar puncture if this test is to be performed with it. For more details on CSF sample collection ask your doctor or get in touch with our customer care team.
Blood or CSF may be used as the specimen for this test. There are no preparations required for blood sample collection. For CSF sample collection your doctor will advise you on any preparations if required.
There are no normal ranges for this test. You will either test positive or negative for the two antibodies.
NMO and associated spectrum abnormalities can be diagnosed by the presence of NMO and MOG antibodies. NMO and NMOSD-positive patients will show the presence of either NMO antibodies or MOG antibodies. A negative result suggests the absence of the disease. Your doctor will guide you on how to interpret your results.
Along with the NMO With MOG Antibody Profile test, your doctor may order the following tests -
- MRI.
- Lumbar Puncture.
- Aquaporin Antibody Test.
- Eye Tests
Neuromyelitis optica (NMO) Antibodies
NMO Antibodies
Myelin oligodendrocyte glycoprotein (MOG) Antibodies
MOG-IgG
Anti-MOG
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