Home Visit
Upload
NMO With MOG Antibody Profile, Serum
Also known as: NMO with MOG Antibody Profile, Serum
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
NABL & CAP Accredited Labs
Accurate & Quality Test Reports
Trusted by Leading Doctors & Hospitals
NMO With MOG Antibody Profile Overview
Neuromyelitis Optica is an inflammatory autoimmune disease causing demyelination of the central nervous system with degradation of the insulating sheath of at least one optical nerve (Neuritis nervi optici) and at the same time or few months later the spinal cord (Myelitis).
Symptoms of autoimmune disorders are brought on when the body erroneously attacks healthy cells. Antibodies carry out these assaults. Our immune system produces these antibodies, which are nothing but proteins specifically designed to prevent pathogens from harming humans. They can attack a variety of bacteria, viruses, and other organisms. Antibodies are vital to the defence mechanisms of our immune system. These antibodies might, however, make errors from time to time. They accidentally target normal healthy cells rather than pathogens and are known as autoantibodies. Depending on whether normal tissue was assaulted, this could result in harm and several problems. A condition of the central nervous system called Neuromyelitis Optica (NMO) is one such autoimmune disease. Here's all you need to know about NMO and the NMO with MOG antibody profile.
What is NMO?
NMO primarily affects the spinal cord (myelitis) and eye nerves (optic neuritis). The precise mechanism through which NMO arises is unknown; it is assumed to be connected to a problem with the blood-brain barrier, which permits auto-antibodies to penetrate the brain and spinal cord and harm and inflame certain cells. The myelin sheath of the brain's nerves is one region that is damaged. Although the autoimmune condition cannot be healed, the patient can have an active life with proper treatment. Since multiple sclerosis, another autoimmune illness can have comparable symptoms but advance in a different way, it is important to distinguish between the two. In incidences of NMO and NMOSD (NMO spectral disorders), respectively, the NMO antibody and MOG antibodies are positive. The NMO with MOG antibody profile test is done to diagnose and evaluate these conditions.
Who should do the NMO With MOG Antibody Profile test?
People with one or more of the following symptoms should do this test -
- A weakened back and arms.
- Tight, uncomfortable spasms in the arms and legs.
- Discomfort in the arms and legs.
- Heightened reactivity to cold and heat.
Problems with the bladder, bowels, and sexuality
Why is the NMO With MOG Antibody Profile test done?
This examination looks for NMO and MOG antibodies. The presence of NMO & MOG antibodies is diagnostic of NMO and related spectral disorders. 80% of NMO patients test positive for NMO antibodies while 20% of patients may test negative, but will test positive for MOG antibodies. This test helps to diagnose and distinguish this disorder from multiple sclerosis.
Written by: Dr Vishal Wadhwa, M.D, D.N.B Microbiology, Medical Affairs
Reasons for Undergoing the NMO With MOG Antibody Profile
There are several key reasons for undergoing the NMO with MOG antibody profile, including:
- Diagnosis: To diagnose inflammatory demyelinating diseases with a phenotype similar to NMOSD, such as optic neuritis, transverse myelitis, and autoimmune MOG-opathy.
- Distinguishing Conditions: To differentiate NMOSD, ADEM, optic neuritis, and transverse myelitis from multiple sclerosis (MS) early in the disease course.
- Clinical Management: To guide treatment decisions and predict the disease course, as MOG-antibody-positive patients often have a different clinical outcome and response to treatments compared to AQP4-antibody-positive patients.
- Excluding Alternative Diagnoses: To rule out other autoimmune or demyelinating conditions and confirm the specific diagnosis of MOG-antibody-associated disease.
List of Parameters Considered During the NMO With MOG Antibody Profile
The primary parameter measured during the NMO with MOG antibody profile is the presence and titer of MOG-IgG antibodies in the patient's serum. These antibodies bind to the MOG protein on the surface of oligodendrocytes and are detected using cell-based assays, such as live cell-based assays or fixed cell-based assays. The presence of these antibodies indicates an autoimmune response targeting the MOG protein.
NMO With MOG Antibody Profile Preparation
Preparation for the NMO with MOG antibody profile involves the following steps:
- A serum sample is collected from the patient, typically requiring 1-2 mL of blood drawn into a red-top tube, gel-barrier tube, or serum transfer tube.
- Ensure that the sample is not grossly haemolysed or lipaemic, as these conditions can lead to rejection of the sample.
NMO With MOG Antibody Profile Results & Interpretation
The results of the NMO with MOG antibody profile are interpreted as follows:
- Positive Result: A high positive result (e.g., titer ≥100) confirms the presence of MOG-IgG antibodies and supports the diagnosis of MOG-antibody-associated disease without needing additional supporting features. Low positive results may require further evaluation to exclude alternative diagnoses.
- Negative Result: A negative result does not rule out NMOSD or other demyelinating diseases but indicates that MOG-IgG antibodies are not present.
- Clinical Correlation: The results should be correlated with clinical presentation, MRI findings, and other diagnostic criteria to confirm the diagnosis.
Home Collection for NMO With MOG Antibody Profile
Metropolis Healthcare offers a convenient home sample collection service for the NMO with MOG antibody profile, ensuring that patients can undergo testing without visiting a clinic. A trained phlebotomist will come to your doorstep to collect the necessary blood samples, maintaining the highest standards of safety, hygiene, and sample handling. This service ensures that there is no compromise on testing accuracy while providing comfort and convenience to the patient.
With Metropolis Healthcare's commitment to making healthcare accessible, you can expect timely and reliable results, empowering you to take proactive steps in managing your health through quality diagnostic solutions delivered conveniently at home.
NMO with MOG Antibody Profile, Serum Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the NMO with MOG Antibody Profile, Serum with a clear pricing structure.
The NMO with MOG Antibody Profile, Serum Price in Antop Hill is ₹ 7,500 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
For Differential diagnosis of NMO from Multiple sclerosis Highly specific serum autoantibody markers are found very frequently in NMO, while they are not detected in Multiple sclerosis (MS) or healthy subjects.
Performed for patients suspected to be suffering from Neuromyelitis optica
Neuromyelitis Optica is an inflammatory autoimmune disease causing demyelination of the central nervous system with degradation of the insulating sheath of at least one optical nerve (Neuritis nervi optici) and at the same time or few months later the spinal cord (Myelitis). NMO AQP4-Ab -are disease specific auto Ab, found in in 70-80% NMO Patients. MOG Antibodies are present in 20% of AQP4 –Seronegative patients with a phenotype of NMOSD (neuromyelitis optica spectrum disorder) MOG antibodies are found in Patients positive for MOG-IgG have a high risk of recurrent disease course
NMO and MOG antibodies are measured by this test.
People who have at least one of the following symptoms ought to take this test:
- Feeble arms and back.
- Leg and arm spasms that are painful and tight.
- Discomfort in arms and legs.
- Increased sensitivity to heat and cold.
- Issues with the bowels, the bladder, and sexuality.
If you experience one or more of the above symptoms that have no explanation, you should immediately consult your doctor. Your doctor may then recommend you take this test to check for NMO.
This test may be recommended by the doctor to identify NMOSD and distinguish it from conditions like multiple sclerosis, longitudinal extensive spinal cord lesions, autoimmune encephalitis, etc. This test also aids in tracking the prognosis and likelihood of NMOSD relapse. The progression of the illness and the effectiveness of the treatment may also be tracked.
For this test, a tourniquet (elastic band) is tightly applied to the upper arm to collect a blood sample. A fist is then requested from the patient. This aids in filling up veins with blood. Before inserting the needle, the skin is cleaned, and a vacutainer is used to collect the drawn blood sample. Your doctor will need to collect cerebrospinal fluid (CSF) through a lumbar puncture if this test is to be performed with it. For more details on CSF sample collection ask your doctor or get in touch with our customer care team.
Blood or CSF may be used as the specimen for this test. There are no preparations required for blood sample collection. For CSF sample collection your doctor will advise you on any preparations if required.
There are no normal ranges for this test. You will either test positive or negative for the two antibodies.
NMO and associated spectrum abnormalities can be diagnosed by the presence of NMO and MOG antibodies. NMO and NMOSD-positive patients will show the presence of either NMO antibodies or MOG antibodies. A negative result suggests the absence of the disease. Your doctor will guide you on how to interpret your results.
Along with the NMO With MOG Antibody Profile test, your doctor may order the following tests -
- MRI.
- Lumbar Puncture.
- Aquaporin Antibody Test.
- Eye Tests
Neuromyelitis optica (NMO) Antibodies
NMO Antibodies
Myelin oligodendrocyte glycoprotein (MOG) Antibodies
MOG-IgG
Anti-MOG
The NMO with MOG antibody profile test is a diagnostic tool that detects antibodies against myelin oligodendrocyte glycoprotein (MOG) in patients suspected of having Neuromyelitis Optica Spectrum Disorder (NMOSD) or other inflammatory demyelinating diseases. It helps identify a specific subset of NMOSD patients.
Yes, some laboratories and diagnostic centres like Metropolis Healthcare offer home sample collection for the NMO with MOG antibody profile test. However, it is crucial to follow the laboratory's guidelines for sample handling and transportation to ensure the integrity of the sample.
The NMO with MOG antibody profile test is used to diagnose and differentiate NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis. It also guides clinical management and treatment decisions based on the specific antibody profile.
The frequency of testing for the NMO with MOG Antibody Profile depends on the clinical scenario.
The NMO with MOG antibody profile test can be done at any time, but it is usually recommended when you present with symptoms suggestive of NMOSD or other related conditions.
No, fasting is not required for the NMO with MOG antibody profile test.
The main precaution is to ensure that the blood sample is not contaminated by gross haemolysis or lipemia.
The primary parameter included in the NMO with MOG antibody profile test is the detection and titre of MOG-IgG antibodies using cell-based assays. The presence and level of these antibodies help diagnose and characterise MOG-antibody-associated diseases.
The test should be done when you present with clinical features suggestive of NMOSD or other inflammatory demyelinating diseases. It is particularly useful when distinguishing these conditions from multiple sclerosis or other autoimmune disorders.
The test itself does not require significant time from you as a patient. The blood sample collection process usually takes only a few minutes, and you can resume your normal activities afterwards.
The turnaround time for the NMO with MOG antibody profile test report may vary depending on the lab. Typically, you can expect to receive the results within 24 hours based on the day/date the sample is collected and processed.
Ratings & Reviews (0)
Why Metropolis?
Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
WhatsApp