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Paraneoplastic syndrome/Neuronal Antibody Profile-3

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Paraneoplastic syndromes are a group of disorders that occur due to the reaction of immune system to the tumour or cancer cells. Paraneoplastic syndromes are characterized by the presence of neuronal autoantibodies in the patient serum. This may result in debilitating conditions affecting the various systems of the body. Paraneoplastic syndrome profile includes a series of tests to detect neuronal autoantibodies.

Written by - Dr.Shibani R, Medical Writer, Medical Affairs

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Paraneoplastic syndrome/Neuronal Antibody Profile-3 Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Paraneoplastic syndrome/Neuronal Antibody Profile-3 with a clear pricing structure.

The Paraneoplastic syndrome/Neuronal Antibody Profile-3 Price in Mumbai is ₹ 16,500 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

The Paraneoplastic syndrome/Neuronal Antibody Profile/Neuronal Antibody Profile-3 detects the antibodies against neuronal antigens like Amphiphysin, Pnma2, Ri, Yo, Hu, Recoverin, Sox-, Titin, GAD-65, Zic4, TR and CV in the blood serum.

People with the following symptoms:

  • Seizures of unknown origin
  • Neurological disturbances like hallucinations, confusions, anxiety, depression.
  • Neuropsychiatric symptoms
  • Patients with certain tumours showing signs of paraneoplastic disorders
  • Neuromyotonia
  • Sudden onset progressive muscle pain and weakness, stiffness, spasms
  • Sudden onset Vision problems

Ambulatory and mobility issues

  • To diagnose paraneoplastic disorders due to certain types of tumours. Tumours that commonly cause paraneoplastic disorders are small cell carcinoma lung, seminoma, breast carcinoma, ovarian carcinoma
  • For diagnosis of autoimmune encephalitis
  • For differential diagnosis in patients with encephalitis of unknown origin
  • Tests are useful in detecting the antibodies against different neurological receptors.

This test requires a blood. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

Specimen Type, Site, Clinical History and Clinician number are required

The presence of specific neuronal autoantibody signifies specific neurological disorder.

Anti – Amphiphysin test

Positive result indicates the presence of autoantibodies against Amphiphysin which may signify neurological disorder (stiff person syndrome)

Anti - CV2/CRMP5 test

Positive result may signify Chorea, Sensory neuropathy, Cerebellar degeneration or Limbic encephalitis.

Anti - PNMA2 (Ma 2 / Ta)

Positive result may indicate limbic & brain stem encephalitis, cerebellar degeneration.

Anti - Ri/ANNA – 2

Positive result may signify brain stem encephalitis

Anti - Yo/PCA – 1

Positive result may signify cerebellar degeneration.

Anti - Hu/ ANNA – 1

Positive result may signify sensory neuropathy, cerebellar degeneration, limbic encephalitis.

Anti Recoverin test

Positive Result may signify tumour associated retinopathy commonly with small cell lung carcinoma

Anti SOX1 test

Positive Result may signify associated with Lambert -Eaton myasthenia syndrome, Paraneoplastic cerebellar degeneration & Neuropathy.

Anti Titin test

Positive Result may signify Myasthenia Gravis.

Anti Zic4 test

Positive Result may signify Small Cell Lung Carcinoma (SCLC), Paraneoplastic Neurological Syndrome(PNS).

Anti GAD65

Positive Result may signify Stiff Person Syndrome(SPS), Small Cell Lung Carcinoma (SCLC), Breast Carcinoma, Colon Carcinoma.

Anti Tr(DNER)

Positive Result may signify paraneoplastic cerebellar Degeneration (PCD), Hodgkins Lymphoma.

Negative result for each test does not rule out paraneoplastic syndrome and should be correlated with the clinical features and other investigations as well.




1. Amphiphysin test

2. Pnma2 test

3. Ri test

4. Yo test

5. Hu test

6. Recoverin test

7. Sox-1 test

8. Titin test

9. GAD-65 test

10. Zic4 test

11. TR test

12. CV2 test

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