Paraneoplastic syndrome/Neuronal Antibody Profile-3

What Does a Neuronal Antibody Profile - 3 Test Measure?

This test measures IgG-type neuronal autoantibodies using the Immunoblot method. Each antibody detected provides insight into a specific neurological or autoimmune condition.

It helps to:

• Detect Paraneoplastic Syndromes: Immune-mediated neurological disorders linked to hidden cancers.
• Diagnose Autoimmune Encephalitis: Inflammation of the brain caused by an immune reaction.
• Identify Underlying Cancers: Certain autoantibodies serve as markers for malignancies such as lung, breast, or ovarian cancer.
• Guide Immunotherapy: Helps doctors plan steroid, IVIG, or plasma exchange treatments.
• Monitor Treatment Response: Used to track antibody activity during and after therapy.

Neuronal Antibody Profile - 3 Test: Who Needs It and Why It’s Done

Symptoms Indicating the Need for This Test

You may need this test if you experience:

• Unexplained seizures, memory loss, or confusion
• Stiffness, tremors, or balance issues
• Double vision or difficulty swallowing
• Persistent dizziness or neuropathy
• Psychiatric symptoms like mood swings, hallucinations, or personality changes
• Rapidly progressive neurological decline

Who Should Get This Test

• Patients with suspected autoimmune encephalitis or paraneoplastic syndromes
• Individuals showing neurological symptoms without clear cause
• People diagnosed with or suspected of having cancers like small cell lung, breast, or ovarian carcinoma
• Patients with chronic neurological or neuromuscular disorders unresponsive to conventional treatment

What Is the Purpose of a Neuronal Antibody Profile - 3 Test?

The main purpose of this test is to identify autoantibodies that attack the nervous system, either due to an autoimmune process or as a reaction to hidden cancer. Detecting these antibodies early helps in:

• Diagnosing autoimmune encephalitis or PNS
• Directing clinicians to search for an underlying malignancy
• Guiding personalised immunotherapy for neurological recovery

Importance of a Neuronal Antibody Profile - 3 Test

This test is critical because paraneoplastic neurological disorders often precede cancer diagnosis. Identifying antibodies such as anti-Hu, anti-Yo, or anti-Ri can alert doctors to search for malignancies even before clinical cancer symptoms appear.

By detecting antibodies early, the test improves outcomes by allowing timely treatment with immunotherapy and cancer management.

Neuronal Antibody Profile - 3 Test Booking & Reports – Metropolis Healthcare

How To Book the Neuronal Antibody Profile - 3 Test and Get Your Reports

1. Simple Online Booking
   Book your Neuronal Antibody Profile - 3 Test through the Metropolis Healthcare website or mobile app. You can choose home collection or visit your nearest Metropolis lab.
2. Safe Home Sample Collection
   Our skilled phlebotomists collect a blood sample safely in a gel vacutainer while maintaining hygiene standards.
3. Sample Tracking Updates
   Track your sample in real-time using the Metropolis website or mobile app.
4. Accurate Laboratory Testing
   Your sample is processed using the Immunoblot method in NABL & CAP accredited laboratories for precise antibody detection.
5. Quick & Reliable Reports
   Get your detailed reports via email, WhatsApp, or by downloading them from the Metropolis website or app.

How Long Does It Take to Get a Neuronal Antibody Profile - 3 Test Report?

Reports are generally available the same day once the sample reaches the laboratory.
Note: Reporting time and cost may vary based on your location.

Is Home Sample Collection Available for the Neuronal Antibody Profile - 3 Test?

Yes, Metropolis Healthcare offers safe home sample collection for this test. Our team ensures comfort and safety while collecting your sample at home.

Guide to Interpreting Neuronal Antibody Profile - 3 Test Results

What Your Neuronal Antibody Profile - 3 Test Results May Indicate

Result Interpretation (Intensity Classes)

What Preparations Are Needed for a Neuronal Antibody Profile - 3 Test?

To ensure accurate results:

• No fasting required – you may eat and drink as usual.
• Provide a detailed clinical and medication history before testing.
• Avoid sample contamination or delay in transport.
• Discuss with your neurologist if you are on immunosuppressants or steroids.

How Is a Neuronal Antibody Profile - 3 Test Done? (Step-by-Step Procedure)

The test is performed through a simple blood collection process:

• Preparation: A tourniquet is applied to your arm to make veins visible.
• Cleaning: The puncture site is cleaned with antiseptic.
• Sample Collection: Around 3 ml of blood is drawn into a gel vacutainer.
• Completion: The needle is removed, and a bandage is applied.
• Processing: The sample is analysed using the Immunoblot technique to detect specific neuronal autoantibodies.

Conditions That May Affect Test Accuracy

Incomplete medical history may limit interpretation accuracy.

Diseases That a Neuronal Antibody Profile - 3 Test Can Help Detect

This test assists in diagnosing:

• Paraneoplastic Neurological Syndromes (PNS)
• Autoimmune Encephalitis
• Stiff-Person Syndrome
• Limbic or Brainstem Encephalitis
• Cerebellar Degeneration
• Myasthenia Gravis
• Sensory Neuronopathy
• Tumour-Associated Retinopathy

Neuronal Antibody Profile - 3 Test Price in Different Cities

The cost of a Neuronal Antibody Profile - 3 Test may vary depending on your location. Here's a table showing the approximate price range for the Neuronal Antibody Profile - 3 Test at Metropolis Healthcare in major Indian cities:

The Neuronal Antibody Profile - 3 Test cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive Neuronal Antibody Profile - 3 Test prices across major cities in India.

References

1. Dalmau J., Rosenfeld M.R. (2008). Paraneoplastic syndromes of the CNS. Lancet Neurology, 7(4), 327–340. PMID: 18339349
2. Graus F., Delattre J.Y., Antoine J.C., et al. (2004). Recommended diagnostic criteria for paraneoplastic neurological syndromes. Journal of Neurology, Neurosurgery & Psychiatry, 75(8), 1135–1140. PMID: 15258213
3. Gresa-Arribas N., Dalmau J. (2012). Autoimmunity to synaptic receptors and neuronal cell surface proteins in neurological disease. Physiological Reviews, 92(2), 531–570. PMID: 22535835
4. Lancaster E., Martinez-Hernandez E., Dalmau J. (2011). Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology, 77(2), 179–189. PMID: 21734183
5. Pittock S.J., Kryzer T.J., Lennon V.A. (2004). Paraneoplastic antibodies coexist and predict cancer, not neurological syndrome. Ann Neurol, 56(5), 715–719. PMID: 15470747