Myositis Profile Test

What Does a Myositis Profile Test Measure?

The Myositis Profile Test detects IgG antibodies against 16 specific muscle-related antigens. These antibodies help identify autoimmune muscle inflammation and its possible complications.

• Autoantibody Screening: Detects antibodies like Jo-1, Mi-2, SRP, TIF1, and NXP2 that cause muscle inflammation.
• Disease Subtype Identification: Differentiates polymyositis, dermatomyositis, necrotising myopathy, and overlap syndromes.
• Cancer and Lung Disease Association: Identifies antibodies linked to malignancy or interstitial lung disease.
• Treatment Planning: Helps guide immunosuppressive or steroid therapy.
• Monitoring Disease Activity: Assists in evaluating disease progression and treatment response.

Myositis Profile Test: Who Needs It and Why It’s Done

What Symptoms May Call for a Myositis Profile Test?

Your doctor may recommend this test if you experience:

• Persistent or unexplained muscle weakness or pain
• Fatigue or difficulty performing daily tasks
• Skin rashes, particularly a reddish or purplish rash on your face, neck, or knuckles
• Trouble swallowing or breathing due to muscle involvement
• Stiffness or inflammation in muscles or joints

Who Should Get a Myositis Profile Test?

This test is advised for:

• People suspected of having polymyositis, dermatomyositis, or overlap syndromes
• Individuals with autoimmune symptoms such as rash, fatigue, or joint stiffness
• Patients with interstitial lung disease of unclear cause
• Those with a family history of autoimmune disease
• Patients undergoing treatment for autoimmune myopathies to monitor response

Why is a Myositis Profile Test Done?

The test helps doctors detect autoimmune inflammation in your muscles and identify the type of myositis you may have. This supports timely diagnosis, accurate classification, and personalised treatment planning.

Importance of a Myositis Profile Test

The Myositis Profile Test offers one of the most comprehensive ways to assess autoimmune muscle inflammation.

• Early Diagnosis: Detects antibodies before symptoms progress severely.
• Accurate Classification: Identifies disease subtype to guide precise treatment.
• Treatment Guidance: Helps doctors tailor immunosuppressive therapy.
• Prognostic Value: Indicates risk of associated complications such as cancer or lung disease.
• Monitoring Tool: Useful for tracking therapy response and remission.

Myositis Profile Test Booking & Reports – Metropolis Healthcare

How to Book the Myositis Profile Test and Get Your Reports

1. Simple Online Booking
   Book your Myositis Profile Test through the Metropolis Healthcare website or app. Choose a convenient time for home sample collection, or visit your nearest Metropolis Lab.
2. Safe Home Sample Collection
   Our trained phlebotomists collect your sample safely at home, following all hygiene and infection-control protocols.
3. Sample Tracking Updates
   Stay informed at every stage through Metropolis Healthcare’s real-time tracking system.
4. Accurate Laboratory Testing
   Your blood sample is processed using the Immunoblot method at our NABL & CAP accredited laboratories for reliable results.
5. Quick & Easy Reports
   Receive your reports promptly via email, WhatsApp, or by downloading them from the Metropolis website or app.

Is Home Sample Collection for Myositis Profile Test Available Near You?

Yes, Metropolis Healthcare offers home sample collection for the Myositis Profile Test. Our expert team ensures safe, timely, and comfortable collection from your home, helping you avoid hospital queues and travel.

How Long Does It Take to Get a Myositis Profile Test Report?

Reports are usually available on the same day once the sample reaches the laboratory.
Note: Reporting time may vary based on your location.

Where Can I See or Get Myositis Profile Test Results?

You can access your reports through the Metropolis Healthcare website or app. You’ll also receive your results via email or WhatsApp, and printed copies are available at your nearest Metropolis Lab.

Interpreting Myositis Profile Test Results

What Your Myositis Profile Test Results May Indicate

Understanding Abnormal Myositis Profile Results by Parameter

How Should You Prepare for a Myositis Profile Test?

You don’t need to make major changes before this test. Follow these easy steps:

• No fasting required: Eat and drink as usual before the test.
• Continue medications: Take your regular medicines unless advised otherwise.
• Hydrate well: Drink enough water before the test to make blood collection easier.
• Inform your doctor: Share your complete medical and treatment history.
• Stay relaxed: Rest adequately before your appointment to reduce stress.

How Is a Myositis Profile Test Done? (Step-by-Step Procedure)

• Preparation: A tourniquet is applied to your upper arm to make veins more visible.
• Cleaning: The skin is cleaned with an antiseptic.
• Blood Draw: A sterile needle is inserted into a vein to draw a blood sample.
• Sample Collection: About 4 ml of blood is collected in a gel vacutainer.
• Completion: The needle is removed, and the site is bandaged.
• Processing: The sample is analysed using Immunoblot technology to detect specific muscle antibodies.

Conditions That May Affect Myositis Profile Test Accuracy

Certain conditions or factors may affect test accuracy:

• Recent immunosuppressive therapy may lower detectable antibody levels.
• Active infection or inflammation can influence antibody titres.
• Incomplete medical history may lead to misinterpretation.
• Improper sample handling (e.g., haemolysed or lipemic samples) may interfere with test results.

Diseases That a Myositis Profile Test Can Help Detect

This test helps identify and manage various autoimmune muscle and connective tissue disorders, such as:

• Polymyositis – autoimmune inflammation of skeletal muscles.
• Dermatomyositis – inflammation with characteristic skin rash.
• Anti-Synthetase Syndrome – myositis associated with lung disease and arthritis.
• Necrotising Myopathy – severe muscle damage due to antibodies like SRP.
• Overlap Syndromes – autoimmune conditions involving both muscle and connective tissue.
• Juvenile Myositis – childhood-onset muscle inflammation.

Myositis Profile Test Price in Different Cities

The cost of a Myositis Profile Test may vary depending on your location. Here's a table showing the approximate price range for the Myositis Profile Test at Metropolis Healthcare in major Indian cities:

The Myositis Profile Test cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive Myositis Profile Test prices across major cities in India.

References

1. Satoh, M., Tanaka, S., Ceribelli, A., et al. (2012). A comprehensive overview of myositis-specific antibodies: new and old biomarkers. Autoimmunity Reviews, 11(12), 831–838. PMID: 22365994
2. Betteridge, Z.E., & McHugh, N.J. (2016). Myositis-specific autoantibodies: an important tool to support diagnosis of myositis. Journal of Internal Medicine, 280(1), 8–23. PMID: 27038760
3. Targoff, I.N., Mamyrova, G., Trieu, E.P., et al. (2006). A novel autoantibody to a 155-kd protein is associated with dermatomyositis. Arthritis & Rheumatism, 54(11), 3682–3689. PMID: 17075819
4. Nakashima, R., Imura, Y., Kobayashi, S., et al. (2010). The clinical significance of autoantibodies to MDA5 in Japanese patients with dermatomyositis. Rheumatology, 49(9), 1726–1733. PMID: 20525791
5. Gunawardena, H., Betteridge, Z.E., & McHugh, N.J. (2009). Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression. Autoimmunity, 42(3), 241–248. PMID: 19462186