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NGS Lung Panel Test
Also known as: Lung Basic Gene Panel by NGS, Tissue**
No special precautions
Recommended for
Male, Female
Report
WIthin 25 Days
Blood test at Home
NABL & CAP Accredited Labs
Accurate & Quality Test Reports
Trusted by Leading Doctors & Hospitals
Lung Basic Gene Panel by NGS, Tissue** Details in Brief
| Also Known As | Multi-gene Panel Testing, Cancer Gene Panel, Tumour Gene Sequencing, Molecular Profiling, Genomic Profiling |
|---|---|
| Purpose | Detects mutations in essential lung cancer related genes, helps in early diagnosis and classification of lung cancer, supports treatment decisions including immunotherapy |
| Preparation | Clinical history with histopathology and IHC report required |
| Fasting | Not required |
| Reporting Time | 25 days |
| Cost | 32,000 |
What is an NGS Panel Test?
An NGS (Next-Generation Sequencing) Panel Test is an advanced laboratory method that allows doctors to rapidly examine a specific set of genes from your DNA. Instead of looking at one gene at a time, this technology can read the genetic code of many genes simultaneously to find any changes, mutations, or abnormalities that may be causing disease.
This test helps detect specific genetic mutations or variations that are known to cause or contribute to diseases, particularly cancer, helping doctors confirm a diagnosis and choose the most effective treatment.
What does the NGS Panel Test measure?
The NGS Panel Test creates a genetic profile of a person's disease, especially cancer, to help doctors understand what is driving the disease at a molecular level. The test measures and identifies:
- Specific Gene Mutations: Changes in the DNA of cancer cells that could be making the tumour grow and spread
- Actionable Targets: Specific genetic markers for which targeted therapy drugs are available
- Prognostic Information: Results that can help predict how aggressive a cancer might be and the likely outcome for the patient
- Inherited Cancer Risk: Inherited gene mutations that increase a person's risk of developing certain cancers
- Treatment Resistance: Information to help doctors understand why a current treatment has stopped working
NGS Panel Test: Who Needs It and Why It's Done
What Symptoms May Call for an NGS Panel Test?
An NGS panel test is not typically ordered based on initial symptoms but rather after a diagnosis has been made or is strongly suspected. The symptoms that lead to the initial diagnosis would be specific to the type of cancer:
- Persistent cough or chest pain (for lung cancer)
- A lump in the breast or underarm (for breast cancer)
- Changes in bowel habits (for colorectal cancer)
- A mole that changes in appearance (for melanoma)
- Unexplained weight loss or fatigue
Who should get an NGS Panel Test?
This test is generally recommended for specific groups of patients:
- Patients diagnosed with cancer, especially advanced or metastatic cancers that have spread
- Patients whose cancer has returned after treatment or is not responding to standard therapies
- Individuals with a strong family history of cancer to check for inherited genetic mutations
- Patients being considered for targeted therapy or immunotherapy to determine eligibility for these treatments
- Patients with specific cancer types including lung, breast, colorectal, ovarian, and melanoma cancers
Why is an NGS Panel Test done?
An NGS panel test is done to enable precision medicine by providing a detailed genetic roadmap of a patient's tumour, allowing doctors to select personalised treatments that are more likely to be effective with fewer side effects.
Importance of an NGS Panel Test
The NGS Panel Test is clinically important because it moves cancer treatment away from a general approach to a highly personalised one. By identifying the exact genetic mutations driving a patient's cancer, doctors can match them with specific targeted therapy drugs designed to attack those mutations.
This leads to more effective treatment with better patient response rates, fewer side effects compared to traditional chemotherapy, and saves valuable time by avoiding ineffective therapies. The test also helps identify resistance mutations and supports therapy monitoring throughout the treatment journey.
NGS Panel Test Booking & Reports – Metropolis Healthcare India
How to Book an NGS Panel Test?
- Simple Online Booking
Booking can be done through the Metropolis Healthcare app or website. Select NGS Panel Test, choose a convenient time slot, and provide your sample directly at the lab. - Sample Tracking Updates
Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. - Accurate Laboratory Testing
Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. - Quick & Easy Reports
Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app.
Is home sample collection for NGS Panel Test available near you?
No, home sample collection for NGS Panel Test is not available at Metropolis Healthcare, as it requires a tissue biopsy sample for analysis.
How Long Does It Take to Get an NGS Panel Test Report?
Reports are usually available after 25 days once the sample reaches the lab.
Where can I see or get NGS Panel Test results?
Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare app to view and download your reports. Additionally, test reports are sent via email or WhatsApp and you also have the option to collect a physical copy directly from the lab.
Interpreting NGS Panel Test Results
What Your NGS Panel Test Results May Indicate
The following table provides guidance on interpreting your NGS Panel Test results based on the genes tested:
|
Parameters |
Result Status |
Clinical Significance |
Treatment Implications |
|
ALK (SNVs, short indels & Fusions) |
Detected / Not Detected |
Pathogenic variants or fusions indicate ALK-positive cancer |
Targeted therapies: Crizotinib, Alectinib, Ceritinib, Brigatinib, Lorlatinib, Ensartinib |
|
BRAF (SNVs and short indels) |
Detected / Not Detected |
May indicate activation of MAPK pathway or resistance to certain therapies |
BRAF ± MEK inhibitors (e.g., Dabrafenib, Trametinib) |
|
EGFR (SNVs and short indels) |
Detected / Not Detected |
Pathogenic mutations indicate eligibility for EGFR-targeted therapy |
Afatinib, Erlotinib, Gefitinib, Osimertinib |
|
ERBB2 (SNVs and short indels) |
Detected / Not Detected |
Activating mutations may drive cancer |
HER2-targeted therapies (e.g., Trastuzumab, Neratinib) |
|
KRAS (SNVs and short indels) |
Detected / Not Detected |
Often associated with resistance to EGFR inhibitors |
KRAS G12C inhibitors (Sotorasib, Adagrasib) or clinical trials |
|
MAP2K1 (SNVs and short indels) |
Detected / Not Detected |
Activating mutations may stimulate MAPK pathway |
MEK inhibitors (e.g., Trametinib) |
|
MET (SNVs, short indels, CNVs and Fusions) |
Detected / Not Detected |
Alterations including exon 14 skipping drive tumor growth |
MET inhibitors, Amivantamab (EGFR-MET bispecific) |
|
NRAS (SNVs and short indels) |
Detected / Not Detected |
Activating mutations may promote tumor proliferation |
Limited targeted options; consider clinical trials |
|
PIK3CA (SNVs and short indels) |
Detected / Not Detected |
Activating mutations stimulate PI3K/AKT pathway |
PI3K inhibitors |
|
TP53 (SNVs and short indels) |
Detected / Not Detected |
Tumour suppressor loss; prognostic significance |
No direct targeted therapy; impacts prognosis |
|
RET (SNVs, short indels & Fusions) |
Detected / Not Detected |
Mutations or fusions indicate RET-driven cancer |
RET inhibitors: Selpercatinib, Pralsetinib |
|
ROS1 (SNVs, short indels & Fusions) |
Detected / Not Detected |
ROS1 fusions indicate eligibility for targeted therapy |
Crizotinib, Lorlatinib, other ROS1 inhibitors |
|
NTRK (1,2,3) (Fusions) |
Detected / Not Detected |
Oncogenic driver fusions |
Larotrectinib, Entrectinib |
Conditions that May Affect NGS Panel Test Accuracy
Several factors can influence your NGS Panel Test results and should be discussed with your doctor:
- Sample quality and tumour content - Insufficient tumour tissue or poor sample preservation may affect results
- Timing of sample collection - Fresh tissue samples generally provide better results than older archived samples
- Previous treatments - Chemotherapy or radiation may alter the genetic profile of tumour cells
- Sample contamination - Normal tissue mixed with tumour tissue can dilute the mutation signals
- Technical limitations - Some mutations may be below the detection threshold of the test
- Tumour heterogeneity - Different parts of the same tumour may have different genetic profiles
How is an NGS Panel Test Done?
The NGS Panel Test involves several carefully coordinated steps to ensure accurate results:
- Sample collection - A tissue biopsy is performed by a specialist to obtain tumour tissue, typically through a needle biopsy or surgical procedure
- Sample preparation - The tissue is processed, fixed in formalin, and embedded in paraffin (FFPE) to preserve the genetic material
- DNA extraction - High-quality DNA is extracted from the tumour cells in the tissue sample
- Library preparation - The DNA is prepared for sequencing by adding special molecular tags and amplifying specific gene regions
- Next-generation sequencing - Advanced sequencing machines read the genetic code of multiple genes simultaneously
- Data analysis - Sophisticated software analyses the sequencing data to identify mutations, fusions, and other genetic alterations
- Report generation - Results are compiled into a comprehensive report with treatment recommendations
How Should You Prepare for an NGS Panel Test?
Preparing for your NGS Panel Test requires coordination with your healthcare team:
- No fasting required - You can eat and drink normally before the test
- Continue regular medications - Take your prescribed medicines as usual unless instructed otherwise by your doctor
- Bring medical documents - Carry your clinical history, histopathology report, and IHC report to the laboratory
- Wear comfortable clothing - Choose easily accessible clothing if a tissue biopsy is required
- Stay hydrated - Drink adequate water before the procedure, especially if blood sample collection is needed
- Inform about medications - Tell your healthcare provider about all medicines, vitamins, and supplements you're taking
Diseases that an NGS Panel Test Can Help Detect
The NGS Panel Test can help identify and guide treatment for several important health conditions:
- Non-small cell lung cancer (NSCLC) - The most common type of lung cancer, helping determine targeted therapy options
- Adenocarcinoma - A specific subtype of lung cancer that often responds well to targeted treatments
- Metastatic lung cancer - Advanced lung cancer that has spread to other parts of the body
- Hereditary cancer syndromes - Inherited genetic mutations that increase cancer risk
- Treatment-resistant cancers - Tumours that have stopped responding to initial therapies
- Recurrent lung cancer - Cancer that has returned after previous treatment
NGS Panel Test/Packages that You Can Book With Metropolis Healthcare
The following table shows related genetic testing options available through Metropolis Healthcare:
|
Test/Package Name |
Purpose/Highlights |
|
Focused panel for EGFR, ALK, and ROS1 mutations in lung cancer |
|
|
Comprehensive profiling for non-small cell lung carcinoma |
|
|
Essential biomarkers for lung cancer diagnosis and monitoring |
NGS Panel Test Prices in Different Cities
The cost of an NGS Panel Test may vary depending on your location. Here's a table showing the approximate prices in different cities:
|
City |
Price |
|
₹32000 |
|
|
₹32000 |
|
|
₹32000 |
|
|
₹32000 |
|
|
₹32000 |
|
|
₹32000 |
Lung Basic Gene Panel by NGS, Tissue** Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Lung Basic Gene Panel by NGS, Tissue** with a clear pricing structure.
The Lung Basic Gene Panel by NGS, Tissue** Price in Irinjalakuda is ₹ 32,000 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
There is no specific best time of day for this test. The timing depends on your doctor's recommendation based on your medical situation, such as after a biopsy or when considering treatment changes.
No, fasting is generally not required for an NGS panel test. The test analyses your DNA, which is not affected by food or drink. Always follow specific instructions from your healthcare provider.
Severe dehydration can make blood draw more difficult but does not change the genetic information being analysed. It will not affect the accuracy of test results, though staying hydrated is recommended.
No special diet is required. Continue taking your regular medications unless your doctor advises otherwise. Inform your healthcare team about all medications, vitamins, and supplements you're currently taking.
The NGS Panel Test usually requires a tissue biopsy, not a blood sample. Tissue provides sufficient DNA for sequencing, enabling accurate detection of genetic mutations and personalised treatment insights.
NGS testing from a tissue biopsy carries risks mainly from obtaining the sample, including bleeding, swelling, pain, bruising, or infection at the site. Your doctor will discuss specific risks beforehand.
This test doesn't have a "normal" range like routine blood tests. Results are reported as "detected" or "not detected" for specific mutations. Your doctor will interpret these findings in the context of your condition.
The NGS Panel Test may also be called Multi-gene Panel Testing, Cancer Gene Panel, Tumour Gene Sequencing, Molecular Profiling, or Genomic Profiling.
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Why Metropolis?
Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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