Karyotyping Test: Overview, Purpose, and Its Cost | Metropolis Healthcare
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Karyotyping Test

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Karyotyping Test Overview

A karyotype test analyses the shape, number, and size of chromosomes. Genes are present in chromosomes in cells. They are parts of deoxyribonucleic acid (DNA) passed down from one's parents. They contain information that defines one's unique traits, such as eye colour and height.

Normally, people have 46 chromosomes in each cell, split into 23 pairs. Half of the chromosomes are from the father, and the other is from the mother.

If the number of chromosomes is more or less than 46, or the shape or size of the chromosomes is unusual, it could indicate the presence of a genetic disease. A karyotype test is frequently done to help identify genetic defects a developing baby has.

What are The Types of Karyotyping Tests?

The two common types of Karyotyping are Product of Conception (POC) and Couple Karyotyping. It aids in the identification of any chromosomal abnormalities in fetuses and parents.

1. POC Karyotyping

It is carried out using samples taken from a miscarried fetus. If the doctor suspects any chromosome abnormalities, they may advise you to do POC karyotyping on the fetus from the lost pregnancy. The other name for POC karyotyping is chromosomal analysis.

2. Couple Karyotyping 

The couple karyotyping is performed on both partners. Chromosome abnormalities are detected using blood samples. However, this can be done with a single partner as well. If the test is conducted on the mother, it is referred to as Karyotyping Single.


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Summary Price Of Karyotyping Test

We are a trusted lab, offering Karyotyping Test with a transparent pricing structure.

The cost of Karyotyping Test in India varies as per the city in India.

The average price of Karyotyping Test ranges from ₹2700 to ₹4200.

The price for the test in the following cities is:

  • Chennai: ₹3,900
  • Delhi: ₹3,200
  • Mumbai: ₹4,200
  • Pune: ₹3,900

Contact Metropolis to book an appointment online.

Frequently Asked Questions

Karyotyping is carried out to:

  • To determine whether an adult's chromosomes contain an alteration that might be passed on to a child.
  • See if a chromosome defect prevents a woman from getting pregnant or if it causes miscarriages.
  • Check to see if a fetus has a chromosomal defect.
  • Karyotyping can also determine whether chromosomal issues led to the fetus's stillbirth.
  • Find the cause of any congenital disabilities or disabilities in a newborn.
  • Assist in determining the best course of treatment for certain cancers.

A karyotype test evaluates the shape, size, and number of chromosomes, which are parts of the cells containing genes. Genes are parts of DNA passed down from one's mother and father. It is usually performed to detect genetic abnormalities that a developing baby has.

Karyotyping test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

Adults may need Karyotyping testing if they:

  • Have issues getting pregnant or their partner pregnant. Occasionally infertility in men or women can be caused by a genetic defect.
  • Have certain blood disorders or cancers. Chromosome changes can occur due to illnesses, including multiple myeloma, lymphoma, leukaemia, or anaemia. Karyotyping can detect these anomalies and help with treatment.
  • Have a family history of particular genetic illnesses. Chromosome analysis can reveal whether one has abnormal chromosomes and how likely it is to be passed on to offspring.
Complete Process
  • Karyotype testing can be performed using almost any tissue or cell from the body. 
  • A blood sample drawn from a vein is typically used for a karyotype test.

Blood sample from a vein

The healthcare worker taking the blood will:

i. Tie an elastic band across the upper arm to prevent blood flow. This enlarges the veins underneath the band, making it easier to insert a needle.

ii. Use alcohol to clean the needle site.

iii. Insert the needle into the vein. They might use more than one needle.

 iv. Affix a tube to the needle to fill it with blood.

v. Untie the band from the arm when enough blood has been collected.

vi. Place a cotton ball or gauze pad above the needle site once the needle is removed.

vii. Bandage the area after applying pressure to the site.

  • A placenta or amniotic fluid sample could be used for testing during pregnancy. Cells from the fetus are extracted utilising chorionic villus sampling or amniocentesis.
  • In addition, a Karyotype Test may be performed via a bone marrow aspiration.
Precautions to Be Taken

There is no particular preparation needed for this test. One can get advice from a genetic counsellor or a specialist doctor to make sound decisions. Before choosing to get a genetic test, request genetic counselling.

After The Test

A blood test carries no substantial risks, although one could experience the following:

  • Light bleeding at the site of the vein puncture.
  • Soreness inside the arms.

Abnormal karyotype test results could indicate that the parent or the child has atypical chromosomes. This could be an indication of genetic illnesses and disorders, like:

  • Edwards syndrome, also referred to as trisomy 18, results in severe problems with the heart, kidneys, and lungs.
  • Down syndrome, trisomy 21, results in intellectual disabilities and developmental delays.
  • Turner syndrome inhibits female traits from developing in girls and women.
  • Patau syndrome results in low birth weight and poor development in the womb.
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