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IgG4 Sub Class Serum Test

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IgG4 Test Overview

IgG4 is a subclass of the immunoglobulin G (IgG) antibody that plays a key role in the immune response. IgG4 antibodies are present in the blood serum of healthy individuals and are involved in the recognition and neutralization of a wide range of antigens, including bacteria, viruses, and other foreign substances. They are particularly important in protecting against chronic infections and in regulating the immune response in autoimmune diseases. However, elevated levels of IgG4 in serum have been associated with several diseases, including autoimmune pancreatitis, sclerosing cholangitis, allergy and IgG4-related disease, a multi-system disorder characterized by fibrosis and inflammation in various organs.

Written By: Supriya Kulkarni, Lead-Content & Training

Reviewed By: Dr. Alap Christry M.D. AVP-Lab Operations & Scientific Business Head-Clinical Chemistry

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IgG4 Sub Class Serum Test Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the IgG4 Sub Class Serum Test with a clear pricing structure.

The IgG4 Sub Class Serum Test Price in Mumbai is ₹ 7,200 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

The IgG4 subclass serum test measures the level of IgG4 antibodies in the blood.

  1. To diagnose IgG4-related disease: The test measures the levels of IgG4 antibodies in the blood, which can help diagnose IgG4-related disease.
  2. To monitor IgG4-related disease treatment: The test can help monitor the effectiveness of treatment for IgG4-related disease by measuring the changes in IgG4 antibody levels over time.
  3. To differentiate IgG4-related disease from other conditions: The test can help differentiate IgG4-related disease from other conditions that may have similar symptoms.
  4. To evaluate autoimmune disorders: The test may be done as part of an evaluation for autoimmune disorders, as IgG4 antibodies have been associated with several autoimmune conditions.
  5. To identify allergens: In some cases, IgG4 antibodies may be involved in allergic reactions, and the test can help identify the specific allergen triggering the reaction.
  6. To assess immune system function: The test can provide information about the overall function of the immune system, as IgG4 antibodies are produced in response to infection and other immune system triggers.

The following symptoms or conditions may suggest the need for an IgG4 Sub Class Serum test:

  1. Autoimmune Disorders: IgG4 Sub Class Serum test can be used to diagnose autoimmune disorders, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, or Sjogren's syndrome.
  2. Allergic Reactions: IgG4 Sub Class Serum test can also be used to diagnose allergies, such as food allergies, pollen allergies, or allergic asthma.
  3. Chronic Inflammation: IgG4 Sub Class Serum test may be ordered in cases of chronic inflammation, such as chronic pancreatitis or sclerosing cholangitis.
  4. Suspicion of IgG4-Related Disease: IgG4 Sub Class Serum test can help diagnose IgG4-related disease, a rare autoimmune disorder that can affect multiple organs in the body.
  5. Suspected Tumors: IgG4 Sub Class Serum test may be ordered if a patient has a tumor or mass, as IgG4-related disease can sometimes mimic tumors.

Elevated levels of IgG4 antibodies in the blood can be associated with certain autoimmune disorders, including autoimmune pancreatitis, IgG4-related disease, and pemphigus vulgaris. If the results of the IgG4 Subclass Serum test are abnormal, it could indicate several things, depending on the context and the specific levels of IgG4 antibodies detected:

  1. Allergic reactions: High levels of IgG4 antibodies may be a sign of an allergic reaction to certain foods, drugs, or environmental allergens.
  2. Autoimmune diseases: Some autoimmune diseases, such as autoimmune pancreatitis or sclerosing cholangitis, are associated with elevated IgG4 levels.
  3. Cancer: In rare cases, high IgG4 levels may be a sign of certain types of cancer, such as pancreatic cancer or lymphoma.

The test involves drawing a small amount of blood from a vein in your arm. A healthcare professional will clean the area with an antiseptic, wrap an elastic band around your upper arm to make the veins more visible, and insert a needle into a vein to collect the blood sample. You may feel a brief prick or stinging sensation when the needle is inserted, but the procedure is generally painless.

No special preparation is required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status.

In addition to the IgG4 subclass serum test, other laboratory tests that may be ordered to aid in the diagnosis of IgG4-related disease or to assess its impact on various organs and systems in the body include:

  1. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) tests: These tests can help assess the extent of inflammation in the body and monitor disease activity.
  2. Complete blood count (CBC): This test measures various components of the blood, including red and white blood cells and platelets, and can help detect anemia, infection, or abnormal blood cell counts associated with IgG4-related disease.
  3. Liver function tests: IgG4-related disease can affect the liver and cause abnormalities in liver function tests such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP).
  4. Kidney function tests: IgG4-related disease can also affect the kidneys and cause abnormalities in kidney function tests such as blood urea nitrogen (BUN) and creatinine.
  5. Autoantibody tests: Other autoimmune diseases can coexist with IgG4-related disease, and autoantibody tests such as antinuclear antibody (ANA) and rheumatoid factor (RF) may be ordered to help rule out other conditions.
  • IgG4 testing
  • IgG4 subclass assay
  • IgG4 blood test
  • IgG4 quantification test

IgG4 allergy test

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