IgG Subclass 2 (IgG2) Serum Test by Nephelometry

The IgG2 serum test measures the levels of IgG subclass 2 antibodies in your blood.

• To evaluate patients with clinical signs and symptoms of humoral immunodeficiency or combined immunodeficiency
• To identify deficiencies or abnormalities in the IgG subclass 2 antibodies, which can affect the body's ability to fight bacterial infections

The IgG2 test may be recommended if

• you have clinical indications such as frequent or severe bacterial infections,
• you are suspected to have humoral immunodeficiency or combined immunodeficiency, or
• you experience recurrent respiratory tract infections, sinusitis, or poor response to vaccinations.

If the test results show lower than normal IgG2 levels, it may indicate an increased susceptibility to bacterial infections. Higher than normal levels could suggest an exaggerated immune response, which may be associated with autoimmune disorders.

A small sample of blood will be drawn from a vein in your arm. The blood sample will be sent to a laboratory for analysis.

• Inform your doctor about any medications you are taking as they might interfere with the test results. Also, tell them if you have any specific requirements.
• Follow your doctor's advice regarding medication adjustments or breaks before the test.

• Total IgG levels: Measures the overall levels of immunoglobulin G in the blood
• IgG Subclass 1, 3, and 4: Measures the levels of other subclasses of IgG antibodies
• Complete Blood Count (CBC): Evaluates different components of blood, including red and white blood cells

Serum IgG2 subclass assay

Humoral immunodeficiency refers to a group of disorders characterised by a deficiency in the production or function of antibodies, specifically those belonging to the immunoglobulin G (IgG) subclass. Combined immunodeficiency involves defects in both antibody production and cell-mediated immunity, leading to an increased susceptibility to infections. These conditions can result from genetic mutations or acquired causes, compromising the body's ability to fight off infections effectively.

The IgG2 test is a blood test that measures the levels of the IgG2 subclass of antibodies in the blood. IgG2 plays a crucial role in responding to bacterial and some viral infections, making this test important for assessing immune function.

Yes, many diagnostic centers offer home sample collection services for the IgG2 blood test. This convenient option allows you to have your blood sample collected by a trained professional in the comfort of your own home.

Normal levels of IgG2 typically range from 1.5 to 6.0 mg/mL, but these values can vary slightly depending on the laboratory and the individual's age and health status. Your healthcare provider will interpret your results based on your specific circumstances.

The IgG2 test is used to assess the immune response, diagnose autoimmune disorders, evaluate chronic infections, and monitor immunodeficiency conditions. It helps healthcare providers gain valuable insights into the functioning of your immune system and guide appropriate treatment decisions.

The frequency of testing depends on the underlying condition monitored. Individuals with chronic infections or autoimmune diseases might require regular monitoring, while others may only need testing once or as needed based on clinical symptoms. Your healthcare provider will advise you on the appropriate testing schedule.

The serum IgG2 test can be done at any time, fasting is generally not required. However, it's always best to follow the specific instructions provided by your healthcare provider or the diagnostic center.

No, fasting is generally not required for the IgG2 test. You can continue with your regular diet and medications unless otherwise instructed by your healthcare provider.

Before getting the IgG2 test, inform your doctor about any medications or supplements you are taking, as some may affect the test results. Additionally, stay well-hydrated and avoid any strenuous activities prior to the test to ensure accurate results.

The IgG2 test specifically measures the level of IgG2 antibodies in the blood. This subclass of antibodies is particularly important for fighting against bacterial and some viral infections.

The IgG2 test should be done as advised by your healthcare provider, typically when there are symptoms or clinical indications suggesting an immune system issue. This may include recurrent infections, suspected autoimmune disorders, or monitoring of existing immunodeficiency conditions.

The blood collection process for IgG2 test is quick and usually takes only a few minutes. The entire process, including preparation and waiting time, may take about 30 minutes to an hour, depending on the diagnostic centre's procedures.

The turnaround time for the IgG2 test results is usually within 28 days, based on the day/time when the sample was collected and processed. However, consult with your healthcare provider or the specific lab for more precise timelines.