HIV 2 RT Qualitative blood test - Metropolis Healthcare
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HIV 2 RT Qualitative blood test



HIV 2 RT Qualitative Blood test is used to detect the presence of viral particles by amplification of viral RNA sequence in plasma. This test can help diagnose patients who are at high risk of contracting HIV infection.

HIV is the main causative agent responsible for catching acquired immunodeficiency syndrome (AIDS). HIV is of two types: HIV-1 and HIV-2. Almost all cases of AIDS globally occur due to HIV-1. HIV-2 is less infectious than HIV-1, with a five to ten-fold reduced rate of heterosexual transmission and a 20-30-fold reduced rate of transmission from mother to baby.

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    According to CDC guidelines, the following are the indications to get HIV 2 RT Qualitative Blood test:

    • The person belongs to an area with a high prevalence of HIV-2
    • Individuals with a history of sharing needles or having sexual partners known to be infected with HIV-2 or belong to endemic areas
    • Patient with a history of transfusions or other non-sterile medical care from endemic areas
    • Children born to a woman with known risk factors for HIV-2 infection.

Your doctor can advise you to take HIV 2 RT Qualitative Blood in the following clinical scenarios:

  • In diagnosing HIV-2 virus infection in suspected patients at an early stage
  • It can guide the doctor to start antiretroviral medicines specific to HIV 2 infection
  • It can help diagnose or eliminate doubts of suspected infection in children born to HIV 2 seropositive mothers

There are two major types of the human immunodeficiency virus, namely; HIV-1, which is prevalent worldwide, and HIV-2, which is more than 55% genetically dissimilar from HIV-1.
HIV-2 is most commonly found in western Africa. Although the presence of infected individuals with HIV-2 is less, it is relatively becoming more common in India.

Owing to the difference in genetics, HIV-1, and HIV-2 antigens are also dissimilar, so a diagnostic test that is developed only to detect HIV-1 will not be competent enough to detect HIV-2. Currently, tests that are sensitive to both types of virus, HIV-1 and HIV-2 are available.

The guidelines mandate to use of a test that is sensitive to HIV-2, particularly when testing an individual who has lived in a country where HIV-2 is prevalent or has had a sexual partner belonging to one of those countries. Additionally, using tests sensitive in detecting HIV-2 becomes more important, if a person has clinical signs of HIV infection but the test, which is sensitive only to HIV-1, comes negative.

Moreover, the line of treatment potent for HIV-1 is not effective for HIV-2. Antiretroviral drugs such as the non-nucleoside reverse transcriptase inhibitor (NNRTI) class are not active against HIV-2. This type of HIV should be treated with an integrase inhibitor, or a protease inhibitor regimen, including efavirenz, rilpivirine, doravirine, etravirine and nevirapine.

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HIV 2 RT Qualitative blood test