back-arrow-image Search Health Packages, Tests & More

Combine screening of Pre-eclampsia & Trisomies

50+ booked in last 3 days


PreEclapmsia (PE) is a pregnancy condition characterized by hypertension occurring after 20 weeks of pregnancy together with proteinurea. PE if not diagnosed and treated early increases the chances of pre-term labour and related complications. Apart from USG and clinical examination, combined pre-eclampsia screening includes certain blood marker tests performed to screen the patient for the risk of PE as well as chromosomal abnormalities. The risk is assessed using a software dependent statistical analysis of risk score done using Foetal Medicine Foundation(FMF) approved assays. For better reliability of results, it is advised to carry out analysis between 11 and 13 weeks.

Written by - Dr. Shibani R, Medical Writer, Medical Affairs

Read More

Combine screening of Pre-eclampsia & Trisomies Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Combine screening of Pre-eclampsia & Trisomies with a clear pricing structure.

The Combine screening of Pre-eclampsia & Trisomies Price in Mumbai is ₹ 3,710 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

Combined screening of Preeclampsia and trisomy measures the Free beta HCG, PAPPa, PLGF and NT levels in the blood serum.

  • The test is used to screen for patients at risk of developing PreEclampsia (PE) during pregnancy.
  • The test if done early helps to prevent PE associated complications later in the pregnancy.
  • Helps the clinician to start the pregnant woman on timely treatment and ensures close monitoring throughout the pregnancy.
  • Helps to monitor cases at risk for foetal abnormalities, intrauterine growth restrictions etc.
  • Helps to detect and rule out chromosomal anomalies and trisomies.
  • Helps in the detection of neural tube defects.
  • Pregnant women at risk or suspected to have foetal anomalies should ideally undergo combined PE screening between 11 and 13 weeks of pregnancy.
  • Pregnant women with previous history of PE or adverse pregnancy outcomes.
  • Those with family history of co-morbidities like hypertension, type 1 or Type 2 diabetes mellitus, obesity, thyroid disorders, kidney disorders etc.
  • Those with an immediate family history of chromosomal abnormalities, Down’s syndrome or Edward syndrome should undergo the screening.


This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer. The maternal clinical history, USG reports, TRF details and other details are mandatory.


hCG Beta Subunit, Serum

In pregnancy, hCG level rise can be correlated with gestational weeks especially in the first trimester. 

Low level may indicate: Foetal death, incomplete miscarriage, threatened spontaneous abortion, ectopic pregnancy etc. 

Pregnancy Associated Plasma Protein-A (PAPP-A) Test

The reference levels depend on the maternal and gestational age. Low levels may indicate fetal abnormalities. Low levels should be correlated with the PIGF test, USG test and clinical history for further diagnosis and risk factor calculation.


PlGF (Placental Growth Factor)

Low levels of PIGF may occur in women at risk of PE. Low levels should be correlated with the PAPP-A test, USG findings and clinical history for further diagnosis and risk factor calculation.


Trisomy 21 and Trisomy 18/13

Risk factor calculation is done to rule out chromosomal anomalies like trisomies and neural tube defects in the fetus.

Based on all the results, software dependent statistical analysis is done for Risk factor calculation. The risk factor calculated are statistical approaches and have limited diagnostic value. Results should be correlated with the clinical history and USG findings.

These are screening tests and hence further confirmatory tests may be required for an appropriate diagnosis.

Beta Human Chorionic Gonadotropin (β hCG) is a hormone that is produced by the placenta during pregnancy. β hCG levels can be correlated with weeks of gestation and thus can help identify pathologic pregnancy & miscarriages.

PAPP-A is a protein produced by the placenta and important for fetal growth and development. PAPP-A is an important biomarker for pregnancy related abnormalities like premature birth, preeclampsia, intrauterine growth restriction.

PIGF is a growth factor protein produced by the placenta and released into the maternal blood. It is important for the growth and development of the foetus.

Apart from the other tests, tests to detect chromosomal abnormalities to rule out trisomy and neural tube defects are also done.

full medical check up

Ratings & Reviews (0)

No reviews available

Why Metropolis?

Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.

We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.

lab image
170+ Advanced Labs
lab image
Trusted by Leading Doctors & Hospitals
lab images
Over 2000+ Scientific Officers
reports image
Proficiency Testing for Accurate Reports

Our Blog

Take a look at some of the related content from our blog

Latest Blogs & News

View More
View all