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Cancer marker profile-Ovarian-Comprehensive

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Ovary is the female reproductive organ mainly responsible for the production of female hormones and has a major role in fertility and sexual functions. Ovarian disorders can often lead to hormonal imbalance and fertility issues. Ovarian cancers or malignancies occur due to formation of abnormal multiplication of cells or tissues leading to the formation of fibroids or mass which can often be cancerous. The diagnosis or initial screening is done by certain cancer marker and some hormonal tests. Cancer markers or tumour markers are proteins produced by the normal cells as well as cancer cells, but are produced in higher levels by the cancer cells. Cancer marker profile- Ovarian-Comprehensive consists of tests to measure the levels of tumour markers in the blood, urine, and other body fluids. This profile test is used along with other tests may be helpful in the diagnosis of ovarian cancer and decide the treatment prognosis. This test should however, not be used in isolation for the diagnosis of ovarian tumours.

WRITTEN BY: Dr.Shibani R Medical Writer, Medical Affairs


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Cancer marker profile-Ovarian-Comprehensive Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Cancer marker profile-Ovarian-Comprehensive with a clear pricing structure.

The Cancer marker profile-Ovarian-Comprehensive Price in Mumbai is ₹ 2,385 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

The Cancer marker profile Ovarian-Comprehensive measures the CA125, CEA, AFP, HCG, LDH levels in the blood.

  • The test along with other specialized tests is used for the initial screening of ovarian cancer cases.
  • The profile tests can be used for monitoring treatment and relapse in patients with ovarian, uterine or even breast cancers. 
  • The test may be used as a prognostic marker for survival following cancer surgeries or any ovarian or uterine surgeries.
  • To know the stage of cancer as well as the metastasis status
  • The test can help detect recurrence, metastasis and residual cancer: This may even include patients with a history of cancer of other organs like breast, lung, pancreas etc.


Ovarian cancer may initially present as:

  • Abdominal pain with bloating
  • Menstrual irregularities
  • Weight fluctuations.
  • Pelvic pain at times accompanied with back pain.
  • Reproductive issues.

Certain high risk patients may also require testing:

  • Patients already undergoing treatment for cancer.
  • Patients who have completed the treatment to know the disease status.
  • Familial history of cancers.
  • Patients with inherited genetic components
  • Patients with endometriosis (painful disorder of the lining of the uterus)
  • Post hormone replacement therapies
  • Early menopause patients.

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.


CEA test

A gross increase of CEA in a patient with compatible symptoms are suggestive of the presence of cancer. The results of this test when done over an interval help monitor condition of the patient and his response to treatment.

CEA levels fall after successful treatment to normal levels in 1-4 months

Levels may increase in certain non-cancerous conditions like smoking, hepatic disease, trauma, ulcerative colitis, pancreatitis, cirrhosis, COPD, Crohn's disease and hypothyroidism.

Patients should do a follow-up testing preferably through the same laboratory as different assays can give different result values on the same sample

CA 125 test

Levels may increase in certain non-cancerous conditions such as menstruation/ pregnancy/ uterine fibroids/ cirrhosis/ hepatitis/endometriosis/ PID.

Test results may be normal in patients with stage I of ovarian cancer.

CA-125 levels fall after successful treatment but continue to increase if there is progression and poor response to treatment

AFP-Alpha Feto Protein Test (AFP Test)

High AFP levels can be seen in hepatocellular carcinoma, non-seminomatous germ cell tumors and yolk sac tumors of the ovary. This test should not be used for diagnosis of cancer in isolation, as both false positive and negatives can occur.

HCG Beta Subunit Serum Test

High levels may occur in ovarian cancer.

False high or low levels may occur due to certain interferences by non-HCg substances.

LDH-Lactate Dehydrogenase Test

Many cancers cause a general increase in LDH levels or an increase in one of its isozymes. Moderate to very high increase in LDH levels is seen in certain carcinomas.

Carcinoembryonic antigen (CEA) is a glycoprotein and its concentration in blood increases in certain tumours i.e., colorectal cancer, medullary thyroid carcinoma, breast, gastrointestinal tract, liver, lung, ovarian, pancreatic and prostatic cancers.

It is often used for monitoring colorectal & gastrointestinal cancer patients and their response to treatment.

CA 125 (cancer antigen 125) is a protein expressed in the epithelium lining the body cavity.

Its concentration in blood increases in cancer of ovaries, uterine fibroids, ovarian cysts as well as in some cases of endometriosis.


AFP is normally made by a foetal liver and yolk sac. The test is done as part of cancer diagnosis to know the liver or pancreatic involvement due to cancer.

Human chorionic gonadotropin [HCG] is a hormone produced by the placenta mainly during pregnancy. In patients with cancer or undergoing treatment these levels may be helpful in the diagnosis of gestational trophoblastic disease (GTD), testicular tumors, ovarian germ cell tumors, teratomas, and, rarely, other human chorionic gonadotropin (hCG)-secreting tumors.

Lactate dehydrogenase (LDH) is an enzyme that is present in heart, liver, muscle and kidney tissues. It is used to screen for tissue damage along with other related tests like LDH isoenzymes. Many cancers cause a general increase in LDH levels or an increase in one of its isozymes.

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We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.

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