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BRCA1/2 TARGETED MUTATION ANALYSIS (FAMILY MEMBERS)
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Blood
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Male, Female
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BRCA Gene Test Overview
Breast and Ovarian cancers are the commonest forms of cancer in women. 5-10% of breast cancers and 15-20% of ovarian cancers are hereditary and are due to a mutation in the cancer gene. Germline mutations in BRCA1 and BRCA2 genes are inherited in an autosomal dominant manner and are associated with an increased risk of breast and ovarian cancer, Fallopian tube, Peritoneal, prostate cancer and melanoma. BRCA gene test detects specific germline mutation in BRCA 1 and BRCA2 that was detected in the index case in the family by PCR- Sanger sequencing.
The BRCA1 and BRCA2 genes are the two that are most frequently impacted in hereditary breast and ovarian cancer. BRCA1 and BRCA2 gene mutations account for roughly 3% of breast cancers (affecting about 7,500 people annually) and 10% of ovarian cancers (affecting about 2,000 women annually).
The BRCA1 and BRCA2 genes often guard you against developing specific tumors. However, some abnormalities in the BRCA1 and BRCA2 genes make them unable to function normally, making it more probable for someone to inherit one of these mutations and develop breast, ovarian, and other cancers. The risk of developing breast or ovarian cancer is not universal among people who inherit a BRCA1 or BRCA2 mutation.
Test Overview
The most frequent types of cancer in women are breast and ovarian. Hereditary cancer is caused by a mutation in the cancer gene and accounts for 5–10% of breast cancers and 15–25% of ovarian cancers. The risk of melanoma, peritoneal, breast, ovarian, fallopian tube, and peritoneal cancer is raised by hereditary germline mutations in the BRCA1 and BRCA2 genes, which are inherited in an autosomal dominant way. With the help of PCR-Sanger sequencing, the index case in the family's BRCA1 and BRCA2 germline mutations were identified, and this test may identify those mutations.
The first step is to gather information about breast and ovarian cancer in your family history and give it to your doctor if you are worried that you might have a BRCA1, BRCA2, or any other mutation linked to breast and ovarian cancer.
Who Should Do the BRCA1/2 TARGETED MUTATION ANALYSIS (FAMILY MEMBERS)?
Patients with early-onset breast and/or ovarian cancer who come from families where these diseases have been diagnosed frequently are prime candidates for BRCA mutations. Because a specific BRCA mutation does not always result in cancer in a specific person, BRCA testing is predictive.
What Other Tests Are Ordered Along with the BRCA1/2 TARGETED MUTATION ANALYSIS (FAMILY
MEMBERS)?
A specific deleterious BRCA1 or BRCA2 gene mutation which has previously been found in a family member is the focus of certain tests. Other assays examine both genes for all known dangerous mutations.
Written by: Dr Vishal Wadhwa, M.D, D.N.B Microbiology, Medical Affairs
BRCA1/2 TARGETED MUTATION ANALYSIS (FAMILY MEMBERS) Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the BRCA1/2 TARGETED MUTATION ANALYSIS (FAMILY MEMBERS) with a clear pricing structure.
The BRCA1/2 TARGETED MUTATION ANALYSIS (FAMILY MEMBERS) Price in Mumbai is ₹ 5,250 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
The BRCA gene test is offered to family members of patients with identified with genetic mutation predisposing them to cancer.
Early risk detection of cancer through genetic testing can help in various ways:
a. Family members with the same mutation are at risk of developing cancer and thus should consult a genetic counsellor for further preventive steps.
b. Positive patients can do reproductive decision planning.
Family relatives of individuals who have been diagnosed with a genetic mutation predisposed to cancer are offered the BRCA gene test. Genetic testing can aid in several ways to diagnose cancer at an early stage -
- Family members at risk of cancer due to the same mutation should speak with a genetic counselor for additional preventive measures.
Positive patients are capable of making reproductive decisions
BRCA gene test identifies mutations in the BRCA1/2 gene and helps indicate a predisposition to breast/ovarian cancer.
BRCA gene test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in a vacutainer.
Mutation not detected
- Positive Result: Mutation that was being targeted has been detected. Patient with pathogenic mutations has a higher risk of developing cancer. Consult a genetic counsellor.
- Negative Results: Mutation that was being targeted has been detected. This does not mean that there are no other pathogenic mutations.
BRCA mutations are most likely in individuals with early-stage breast and/or ovarian cancer who come from families where these diseases have been often found. Because a specific BRCA mutation may not always result in cancer in a specific person, BRCA testing is predictive.
The BRCA1 or BRCA2 mutation may be of value to our family members. Tell your relatives about your mutation so they are aware of it. Families can pass on BRCA1 and BRCA2 mutations. Breast, ovarian, as well as other cancers are more likely to affect someone who carries a BRCA1 or BRCA2 mutation.
The risk of BRCA1 and BRCA2 mutations can be determined by genetic counseling and testing. The very same mutation that you have should be checked for if they decide to get tested.
Breast and ovarian cancer can be detected earlier or prevented with the right precautions.
Please consult your physician for specific guidelines.
BRCA gene test
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We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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