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Atherosclerosis Profile - 2 Overview
Atherosclerosis is the deposition of fats/cholesterol in the blood vessels leading to formation of plaques. This blocks or clogs the blood vessel leading to impaired blood supply to the vital organs of the body. Blood vessels of the heart are most commonly affected leading to coronary artery disorders. Cardiovascular disease is the top cause of death for heart attacks and strokes, in asymptomatic people. Risk factors including age, smoking status, hypertension, diabetes, cholesterol, and HDL cholesterol are used by physicians to identify individuals likely to have an ischemic event & to evaluate cardiovascular risk. The test measures the various parameters that can lead to atherosclerosis or formation of plaques.
Blood vessels of the heart are most commonly affected. This leads to coronary artery disorders. They can lead to atherosclerosis or the formation of plaques. This in turn leads to cardiovascular disease. It is the major cause of death among most adults. It leads to heart attacks and strokes, in asymptomatic people.
What is atherosclerosis?
Atherosclerosis is the deposition of fats/cholesterol in the blood vessels. This leads to the formation of plaques. This blocks or clogs the blood vessel. This leads to an impaired blood supply to the vital organs of the body.
Who should do the test?
People with the following markers or lifestyle habits are advised to go for an atherosclerosis test:
- High cholesterol levels
- High body fat levels- obese
- Have type 1 diabetes
- Indulge in smoking
- Consume a diet comprising highly saturated fats
What other tests are ordered along with Atherscelerosis Profile 2?
Other tests included in the package are:
Lipid Profile - Mini
This panel includes:
- Cholesterol - LDL
- Cholesterol - HDL
- Cholesterol - Total
- Low-Density Lipoprotein
Atherosclerosis Profile - 1
This panel includes:
- Cholesterol- Total
- Lp (a)
- Apolipoproteins B/A1
Atherosclerosis Profile- 3
This panel includes:
- Other markers mentioned above
Lipid Profile Maxi
This panel includes:
- Lp (a)
- Apolipoproteins B/A
CREATED BY : Dr.Shibani R Medical Writer, Medical Affairs
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Frequently Asked Questions
Atherosclerosis test is basically done to assess the status of the blood vessels of the heart and the risk of cardiac diseases, stroke, and peripheral vascular diseases. The cholesterol tests measure the levels of individual cholesterols in the blood. Lp (a) serum test is prescribed to understand how well the cholesterol is transported in the body. This gives a more detailed idea of the risk of heart diseases than the routine cholesterol screening and may help in early detection of potential cardiovascular problem. Apolipoproteins B/A is a test that can help predict cardiovascular risk in patients. It gives a more detailed idea of the risk of heart diseases than the routine cholesterol screening. Lp-pla2: It is a vascular-specific inflammatory biomarker providing information on risk for atherosclerotic cardiovascular disease (CVD). It is useful in cases of early stage heart diseases, family history of hypercholesterolemia and blood vessel diseases having normal triglycerides and total cholesterol levels. Homocysteine: Homocysteine is a type of amino acid used to make proteins. Vitamin B12, vitamin B6, and folic acid helps to break down homocysteine and change it into other substances your body needs. Abnormal homocysteine levels increase the predisposition to heart diseases. HsCRP: C Reactive Protein is an acute phase reactant in inflammation. High-sensitivity CRP is a useful test for determining risk of CVD, heart attacks, and strokes and evaluating a person before development of one of these health problems.
The test measures the Cholesterol-Total, HDL, Non HDL, LDL, VLDL and Triglycerides, Lp(a), Apolipoproteins B/A1, Lp-PLA2, HsCRP, Homocysteine levels in the blood.
The cholesterol tests measure the levels of individual cholesterols in the blood.
Lp (a) serum test analyzes how well the cholesterol is transported in the body.
Apolipoproteins B/A is a test. It predicts cardiovascular risk in patients. It gives a more detailed idea of the risk of heart disease.
Lp-pla2 is a vascular-specific inflammatory biomarker. It provides information on the risk of atherosclerotic cardiovascular disease (CVD).
Homocysteine is a form of amino acid. Abnormal homocysteine levels point out a predisposition to heart diseases.
HsCRP: High-sensitivity CRP is a great test for diagnosing the risk of developing CVD, heart attacks, and strokes.
This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.
During the test, a small sample of blood will be taken from your arm via a vein. The sample will then be sent to a laboratory for analysis.
You may experience minor discomfort during the blood draw. However, this should go away quickly. Once the procedure is over, you can resume your normal activities.
Maintaining lipid levels within the desirable ranges helps lower risk of heart attacks and stroke. Low HDL levels (below acceptable levels) are associated with increased risk for Atherosclerotic Cardiovascular disease (ASCVD) . High levels of Non HDL Cholesterol (above acceptable levels) are associated with increased risk for Atherosclerotic Cardiovascular disease (ASCVD). High lipoprotein (a) levels lead to cholesterol being deposited in the arterial walls which causes thickening or clogging of the arterial walls also known as ""atherosclerosis"". This disrupts the flow of blood to the heart and other vital organs. This increases the risk of heart diseases, strokes, and other peripheral arterial diseases. High B/A1 ratio increases the risk of heart diseases. Low ratio may reduce the risk of cardiac diseases and stroke. Apo-B/A1 ratio is a more specific test that gives a clearer picture of the risk of heart diseases as compared to routine cholesterol tests. High Lp- PLA2 levels may indicate need for more aggressive lipid lowering therapy to reduce the risk of CVD events. Patient with high levels are prone to rupture of plaque and associated cardiovascular events Low levels may mean that Lp- PLA2 levels are not contributing to the heart disease. High Homocysteine levels is also an important marker for risk assessment of coronary artery disease. High HsCRP is a sensitive predictor of increased cardiovascular risk in both men and women. It is used for assessment of risk of developing Myocardial infarction in patients presenting with Acute coronary syndrome. It also assesses risk of developing Cardiovascular disease or ischemic event in individuals who do not manifest disease at present.
Before the test, the patient might be asked to fast for 12 to 14 hours for optimal results.
Cholesterol- Total: Less than 200 mg/dL.
HDL: 40 mg/dL or higher
Non-HDL: Within 130 mg/DL
LDL: Less than 130 mg/dL.
VLDL: Anywhere in the range of 2 to 30 mg/DL
Triglycerides: Below 150 mg/dL for adults.
Lp (a): Within 30 mg/DL
Apolipoproteins B: Within 100 mg/DL
Apolipoproteins A1 Men:: 110 to 180 mg/DL
Apolipoproteins A1 Women: 110 to 205 mg/DL
Lp-PLA2: Less than 160 ng/mL.
HsCRP: Less than 3 mg/L.
Homocysteine: Between 5 and 15 micromol/L.
The most significant one is an aneurysm. It has no symptoms. It is life-threatening. This is because it causes internal bleeding.
An anti-inflammatory diet comprising fresh fruits, vegetables, lean protein and high fibre is highly recommended.
Lipid Profile Test
Lipoprotein a Test
Apolipoproteins B Test
Apolipoproteins A1 Test
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