3-Methyl Histidine Quantitative Serum Test

This test measures the levels of 3-Methyl histidine in your blood.

This test is helpful in diagnosing muscular disorders and assessing their severity. It may be used to

• Diagnose muscle atrophy caused by disuse or diseases such as muscular dystrophy.
• Monitor the effectiveness of treatment for muscular disorders.
• Assess nutritional status and monitor protein intake.

Your doctor may recommend this test if you have

• Symptoms suggestive of muscle weakness, such as difficulty climbing stairs or lifting objects.
• A previous diagnosis of muscular dystrophy or other muscle disorders.
• A history of prolonged immobilisation.
• Nutritional deficiencies or malabsorption syndromes that affect protein metabolism.

Low levels of 3-Methyl histidine suggest decreased protein breakdown, while high levels can indicate muscle wasting due to disuse or disease.

For this test, a healthcare professional will draw a blood sample from your arm. The procedure is quick and relatively painless. 

To prepare for this test:

• Fast for at least 8 hours before the test; only water is allowed.
• Inform your doctor of all medications and supplements you are taking before the test, as some drugs may interfere with the results.
• Please reach out to your healthcare provider for any specific requirements.

Other tests that may be ordered alongside this test include the following:

• Creatine kinase testing: This test measures the levels of an enzyme that indicates muscle damage or injury.
• Electromyography (EMG): This evaluates nerve and muscle function.
• Magnetic Resonance Imaging (MRI): This images the body to detect muscle abnormalities.

3MH test or 3-MH quantitative test

Muscular dystrophy is a group of disorders characterised by progressive muscle weakness and wasting due to a genetic mutation. Symptoms usually begin in childhood and worsen over time, leading to difficulty walking, standing, and performing daily activities.