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Apolipoproteins (A1/B)

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An Apolipoproteins Test measures the amount of low density lipoproteins (LDL) in the blood.

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    Doctors usually order both an apo A-I (associated with HDL (HDL), the "good" cholesterol) and an apo B regulate an apo B/apo A-I ratio. This ratio is utilised as an alternate to a total cholesterol/HDL ratio to assess the risk for developing CVD.
    Apo B levels could also be ordered to inspect the effectiveness of lipid treatment as substitute to non-HDL-C (non-HDL-C is the total cholesterol concentration minus the amount of HDL).

Your doctor may recommend this test for you if he suspects that you may have an increased chance of heart disease. You may need this test if you have had a heart attack in the past.

Apo-A is a protein that plays a vital role in lipid metabolism, and is one of the important components attached to HDL or “good cholesterol”. HDL performs a critical role in removing excess of cholesterol from the cells, transporting it to liver where its gets recycled or disposed. Thus, the amount of APO-A present in the blood directly correlates to the HDL levels, and similarly, deficiencies of APO-A is associated with increased risk of developing cardiovascular disease.
Similar to Apo-lipoprotein A1, Apo B is also a protein that is involved in the metabolism of lipids and is the main protein constituent of lipoproteins such as very low-density lipoprotein (VLDL) and LDL (LDL, the "bad cholesterol"). Concentrations of Apo B are directly proportional to LDL-C.

Reference Values

Reference Value depends on age, gender and medical history. A normal Reference Value is listed below:

  1. Apolippoproteins A1 – 110 - 205 mg/dl
  2. Apolipoproteins B – 55 – 140 mg/dl
  3. Apolipoprotein A1/B Ratio: 0.76 – 3.23

Interpretations

Low levels of apo A-I are associated with low levels of HDL, indicating problems in the clearance of cholesterol from blood.  Low levels of apo A-I, along with high concentrations of apo B, are linked to an increased risk of CVD.

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Apolipoproteins (A1/B)

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