ASMA Smooth Muscle Antibody Serum Test - Metropolis Healthcare
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ASMA Smooth Muscle Antibody Serum Test



An anti-smooth muscle antibody (ASMA) test detects antibodies that attack smooth muscle.

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    To help diagnose autoimmune hepatitis and distinguish it from other causes of liver injury

Your doctor would recommend this test for you if you have chronic liver disease or when you have, he needs to check if you have AIH which is autoimmune hepatitis.

AIH signs and symptoms include:

  • Hepatomegaly which is enlarged liver
  • Abdominal swelling
  • Tenderness on the liver
  • Darker urine
  • Pale-coloured stools

The test measures the amount of smooth muscle antibodies (SMA) in your blood. SMAs are proteins made by the body’s immune system to who target their own cytoskeletal proteins. The production of SMA is strongly indicative of autoimmune hepatitis but may also be seen in other forms of liver disease and with other autoimmune disorders such as primary biliary cirrhosis.

Reference Values Of ASMA Smooth Muscle Antibody Serum Test

  • Normal: Negative titer
  • Positive: 1:40
  • Strongly positive: ≥1:80


When significant amounts of SMA and ANA are present in the blood, it most likely indicates the presence of an autoimmune disorder. When SMA and ANA are present, then systemic lupus erythematosus can be significantly ruled out (ANA will be positive with lupus, but ASMA will not).

When anti-F-actin antibodies are shown to be present in substantial quantities in a patient with clinical signs of autoimmune hepatitis, then it is likely that the patient has the condition. In most cases, if the anti-F-actin is positive, then the SMA will also be positive. Since actin is only one of several cytoskeleton proteins, it is possible for a person to have smooth muscle antibodies even when the anti-F-actin test is negative.

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ASMA Smooth Muscle Antibody Serum Test