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G6PD Test — Glucose 6 Phosphate Dehydrogenase Test

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G6PD test measures the levels of glucose-6-phosphate dehydrogenase (G6PD) which is an enzyme in your blood

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    G6PD deficiency is characterized by abnormally low levels of glucose-6-phosphate dehydrogenase, a critical substance that maintains the integrity of RBC protecting it from damage or premature breakdown. G6PD deficiency is the most common human enzyme defect. There is no specific treatment, other than avoiding known factors that can trigger hemolysis. 

    G6PD enzyme testing is essentially performed when an individual has signs and symptoms associated with haemolytic anaemia. A doctor may recommend the test before prescribing medications that are known to cause hemolysis if the patient has G6PD deficiency in conditions when the doctor is unaware of the G6PD deficiency status of the person.

Your doctor may recommend this test for you if you complain of constant fainting, fatigue, if you are suffering from jaundice, rapid heart rate or if you have an enlarged spleen.

Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) also known as favism (after the fava bean) is an X-linked (hence predominantly seen in men) and is a genetic disorder due to defect in a particular gene. This deficiency increases the tendency of and makes the patient more likely to hemolysis (spontaneous destruction of red blood cells) and it leads to jaundice. Various factors trigger it including food, illness and certain medications.

Reference Values

The test report will indicate whether a patient has G6PD deficiency or not.  The normal range of GPPD level is 5.5 to 20.5 units/gram of hemoglobin. Any values that are more than 10% lower than these stipulated values indicate G6PD deficiency. Normal values range differs within laboratories and according to the method employed.

Interpretations

Glucose-6-phosphate dehydrogenase deficiency is one of the most common enzyme deficiencies globally responsible for causing a wide range of diseases. Thus, positive results may indicate that the person may also be suffering or is likely to suffer from disorders such as hyperbilirubinemia, acute hemolysis, or chronic hemolysis, and needs further diagnosis and appropriate treatment. The patient should avoid several foods such as blueberries, fava beans, all berries, red wine and soya products etc.

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G6PD Test — Glucose 6 Phosphate Dehydrogenase Test

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