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C3-Complement

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Complement C3 is a blood test that assesses the activity of a some proteins that are a part of the complement system. 

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    To determine whether deficiencies or abnormalities in complement system proteins are contributing to increased infections or increased autoimmune activity; to help monitor the activity and treatment of autoimmune diseases and immune complex-related diseases.

Your doctor would recommend this test for you if you have the following symptoms:

  1. Fungal infection
  2. Malaria
  3. Paroxysmal nocturnal hemoglobinuria (PNH)

The complement system is complex and composed of a set of more than 30 circulating blood proteins that work together to promote immune and inflammatory responses. Its principal role is to destroy foreign pathogens like bacteria and viruses. The complement system can also be activated when the body makes antibodies against its own tissues that it thinks are foreign (autoantibodies) as happens in autoimmune diseases. Complement tests measure the number or activity of complement proteins within the blood.

Reference Values

 

Gender

Age Range Type

Value mg/dL

Male

Less than or equal to 1 years

58-149

Male

Between 1 - 17 years

80-156

Female

Less than or equal to 1 years

58-151

Female

Between 1 - 17 years

84-168

Male

Greater than 17 years

90-180

Female

Greater than 17 years

90-180

 

Interpretations

Complement levels can also be decreased because of increased consumption or, more rarely, a hereditary deficiency. Hereditary deficiency in one among the complement proteins will usually cause a high frequency of recurrent microbial infections. Decreased complement levels are associated with an increased risk of developing an autoimmune disease. Both C3 and C4 levels are typically depressed in SLE while C3 alone is low in septicaemia and infections caused by fungi or parasites such as malaria.

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C3-Complement

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